Silica, Nanoparticles,
trumeric, drug delivery, cancer,
diabetes, nanomedicine, biomedical science
Abstract
Silica nanoparticles offer a promising platform for the delivery of drugs, in particular for the drugs which lack water solubility, target capability and have non-specific distribution, systematic toxicity and low therapeutic index. In this review, we focus on the synthesis and therapeutic (particularly, anti-cancer) applications of Curcumin loaded Silica Nanoparticles. Various surface modifications of silica nanoparticles have been discussed that are used to enhance their therapeutic applications. The characterization techniques and study of their biocompatibility have also been presented.
Curcumin Silica Nanoparticles
Cite as: Pant, P., Gupta , C., Kumar, S., Grewal, A., Garg, S., & Rai, A. (2020). Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review. Journal of Materials NanoScience, 7(1), 1-18.
β-lactams, monobactam,
antimicrobial drug resistance, biological activity,
multi target drugs
Abstract
The heterocycle moieties form the site of reaction in many enzymes and co-enzymes and also act as an important pharmacophore in the pharmaceutical drug designs. 2-Azetidinones are the 2-carbonyl derivatives of azetidine, more commonly known as β-lactams. These structural entities occupied a central role in the vigil against bacterial infections over the past few decades. A subclass of these heterocyclic systems, monobactams or monocyclic β-lactam derivatives exhibits several biological activities including antibacterial, antifungal, antiprotozoal, anti-mycobacterial, anti-HIV, antiviral, antimalarial, antioxidant, apoptotic inhibitors, anti-inflammatory activity, anticancer activity, herbicidal activity, etc. Monobactams has resistant to the β-lactamase enzyme and could be a reasonable starting point for developing new drugs or inhibitors. In the present review, pharmacological activities of monocyclic β-lactam derivatives have been discussed with respect to current research in the structure-activity relationships in different therapeutic areas.
b-lactam derivatives as drug
Cite as: Rajneesh, K., Singh, R., Ahlawat, P., Kaushik, P., & Singh, K. (2020). Contemporary advances in therapeutic portfolio of 2-Azetidinones. Chemical Biology Letters, 7(1), 13-26.
Keywords: Drug delivery, Nanomedicine, Nanobiotechnology, Liposome, Nanoparticles, Hydrogels, Aptamer
Abstract
Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.
Drug delivery system for breast cancer
Cite as: Mittal, P.; Singh, S.; Singh, A.; Singh, I. K. Current Advances in Drug Delivery Systems for Treatment of Triple Negative Breast Cancer (TNBC). Chem Biol Lett 2020, 7(1), 1-12.
The present study investigated the effect of monocrotophos, a commonly used organophosphate pesticide exposure in the kidney tissues of the swiss albino mice. Monocrotophos was administered at the sub-lethal doses of 1.25mg/kg, 2.5 mg/kg and 5.0 mg/kg body weight for 24 hr. Monocrotophos toxicity generated oxidative stress in the mice as evidenced by significant decrease in the activities of glutathione, superoxide dismutase and catalase enzymes. The exposure increased the lipid peroxidation and protein oxidation in a dose dependent manner. Oxidative stress generation also elicited cytotoxic effects on the mice kidney which were supported by the histopathological changes like degeneration in glomerulus, bowmen’s capsule and tubules, hemorrhage, mononuclear cell infiltration, tubular cast and congested blood vessels in a dose-dependent manner. In conclusion, the study indicated that monocrotophos exposure at various doses induces significant deleterious health effects in mice kidney tissues via oxidative stress generation.
Cite as: Devi, S., Singh, J., Kumar, V., & Malik, V. (2019). Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice. Chemical Biology Letters, 6(2), 39-45.
Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.
Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.
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Coumarin, triazoles and thiazolidinones are one of the most preferred and high valued scaffolds frequently used in medicinal chemistry. The synthesis of newly designed coumarin based triazolyl-thiazolidinones was performed and new compounds were obtained in good yields. The listed compounds were evaluated for their apoptotic activity and determined the minimal inhibitory concentrations for each of the compound on SCC-4 cells using MTT viability test. Furthermore, apoptotic inducer activity was assayed by detecting the expression of caspase-3, a key apoptotic enzyme.
Cite as: FNU, P., Sinha, N., Kumar, S., FNU, A., Kumar, S., Kumar, P., Pandey, A., Sharma, P., Aggarwal, V., FNU, P., Mothsra, P., Singh, B., Singh, R., & Kumar, Y. (2019). Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3. Chemical Biology Letters, 6(2), 30-38.
Antiproliferative effect of Mosinone-A on expression of apoptotic and cell cycle associated proteins in DMBA induced hamster buccal pouch carcinogenesis
Sugunadevi Govindasamy1, Anbu Singaravelu2
and Suresh Kathiresan3
1Assistant Professor, Department of Biochemistry, Dhanalakshmi Srinivasan College of Arts & Science for Women (Autonomous), Perambalur -621212 2Assistant Professor, Department of Biochemistry, Sacred heart college (Autonomous), Thirupattur -635 601 3Associate Professor, Department of Biochemistry& Biotechnology, Annamalai University, Annamalai Nagar.
Abstract
The present study aimed to investigated the antiproliferative potential of Mosinone-A on cell proliferation, apoptosis and cell cycle proteins during 7, 12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch (HBP) carcinogenesis. A total number of 40 golden Syrian hamsters were randomized into 4 groups of 10 animals in each. Group I animals were served as untreated control. Groups II and III animals were painted with 0.5% DMBA in liquid paraffin three times per week for 14 weeks on the left buccal pouches. Group III animals were orally administered with Mosinone-A (2 mg kg-1 b.wt) starting one week before the exposure to the carcinogen and continued on days alternate to DMBA painting, until the sacrification of the animals. Groups IV animals were received Mosinone-A alone throughout the experimental period. Topical application of DMBA for 14 weeks induced buccal pouch carcinomas associated with increased expression of Cox-2, P21, iNos and SIAT1 whereas decreased expression of Bax, Cleaved caspase-9, P12DOC-1, p16INK4A and p15INK4B. Oral administration of Mosinone-A significantly inhibited the development of HBP carcinomas as revealed by decreased expression of Cox-2, P21, iNos and SIAT1 and over expression Bax, Cleaved caspase-9, P12DOC-1, p16INK4A and p15INK4B. The result of the present study indicates that Mosinone-A can exerts protective effects against DMBA induced buccal pouch carcinogenesis by inhibiting cell proliferation and inducing differentiation and apoptosis.
Note: this manuscript has been removed from journal due to ‘no response from authors’. It was reviewed and accepted by editor for consideration in Chemical Biology Letters, however, authors did not respond to emails and reminders for required revisions and submission of revised/updated manuscript.
UGC funded National Conference on Recent Advances in Chemical Sciences towards Green and Sustainable Environment – Swachh Bharat Abhiyaan Perspective RACSGSE-SBAP 2017
Organized by
Department of Chemistry Aditi Mahavidyalaya University of Delhi Delhi, India
