urn:nbn:sciencein.cbl.2019v6.113
Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3
Published in Chemical Biology Letters
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Pooja FNU
University of Delhi
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Nimisha Sinha
University of Delhi
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Sonu Kumar
University of Delhi
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Atul FNU
University of Delhi
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Sumit Kumar
University of Delhi
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Prashant Kumar
SRM University
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Abhishek Pandey
University of Delhi
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Pragya Sharma
University of Delhi
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Vithika Aggarwal
University of Delhi
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Poonam FNU
University of Delhi
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Poonam Mothsra
University of Delhi
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Brajendra Kumar Singh
University of Delhi
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Rishi Pal Singh
University of Delhi
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Yogesh Kumar
University of Delhi
Keywords:
Apoptotic inducer activity, anti-cancer,
anti-tumor, breast cancer, enzyme
inhibition, medicinal chemistry
Abstract
Coumarin, triazoles and thiazolidinones are one of the most preferred and high valued scaffolds frequently used in medicinal chemistry. The synthesis of newly designed coumarin based triazolyl-thiazolidinones was performed and new compounds were obtained in good yields. The listed compounds were evaluated for their apoptotic activity and determined the minimal inhibitory concentrations for each of the compound on SCC-4 cells using MTT viability test. Furthermore, apoptotic inducer activity was assayed by detecting the expression of caspase-3, a key apoptotic enzyme.
Cite as: FNU, P., Sinha, N., Kumar, S., FNU, A., Kumar, S., Kumar, P., Pandey, A., Sharma, P., Aggarwal, V., FNU, P., Mothsra, P., Singh, B., Singh, R., & Kumar, Y. (2019). Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3. Chemical Biology Letters, 6(2), 30-38.
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