Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3

urn:nbn:sciencein.cbl.2019v6.113

Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3

Published in Chemical Biology Letters

  • Pooja FNU

    University of Delhi

  • Nimisha Sinha

    University of Delhi

  • Sonu Kumar

    University of Delhi

  • Atul FNU

    University of Delhi

  • Sumit Kumar

    University of Delhi

  • Prashant Kumar

    SRM University

  • Abhishek Pandey

    University of Delhi

  • Pragya Sharma

    University of Delhi

  • Vithika Aggarwal

    University of Delhi

  • Poonam FNU

    University of Delhi

  • Poonam Mothsra

    University of Delhi

  • Brajendra Kumar Singh

    University of Delhi

  • Rishi Pal Singh

    University of Delhi

  • Yogesh Kumar

    University of Delhi

Keywords:

Apoptotic inducer activity, anti-cancer,
anti-tumor, breast cancer, enzyme
inhibition, medicinal chemistry

Abstract

Coumarin, triazoles and thiazolidinones are one of the most preferred and high valued scaffolds frequently used in medicinal chemistry. The synthesis of newly designed coumarin based triazolyl-thiazolidinones was performed and new compounds were obtained in good yields. The listed compounds were evaluated for their apoptotic activity and determined the minimal inhibitory concentrations for each of the compound on SCC-4 cells using MTT viability test. Furthermore, apoptotic inducer activity was assayed by detecting the expression of caspase-3, a key apoptotic enzyme.

Cite as: FNU, P., Sinha, N., Kumar, S., FNU, A., Kumar, S., Kumar, P., Pandey, A., Sharma, P., Aggarwal, V., FNU, P., Mothsra, P., Singh, B., Singh, R., & Kumar, Y. (2019). Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3. Chemical Biology Letters, 6(2), 30-38.

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