Category: Medicinal Science

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Immunoendocrine regulation of energy homeostasis and male reproduction

Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.

This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.

Potential topics include but are not limited to the following:

  • Energy homeostasis  and male reproduction
  • Immunoendocrine regulation of male reproductive functions
  • Adipokines and energy metabolism in male fertility
  • Obesity and male infertility: energy imbalance to inflammation
  • Endocrine regulation of epigenetics of reproductive tract inflammation
  • Altered energy metabolism and immune regulation in aged men
Submission Deadline 30th June 2021
Publication Date 1st Sept 2021

Guest Editors:

Pallav Sengupta, PhD
Department of Physiology
Faculty of Medicine & Biomedical Sciences
MAHSA University
[pallav@mahsa.edu.my; pallav_cu@yahoo.com]
Sulagna Dutta, PhD
Department of Physiology
Faculty of Dentistry
MAHSA University
[duttasulagna@mahsa.edu.my; sulagna_dutta11@yahoo.com]

Submission

Article (Research articles and Review Articles) should be submitted online on the journal site http://www.thesciencein.org/journal/index.php/cbl as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

There is no publication charges for publishing in special issue or in Chemical Biology Letters.

Indian Women Scientists in Material Sciences, NanoSciences and Nanobiotechnology

The Indian Women in Science have shown their matte in past, and continuously have an impactful contribution in the advanced research fields with a notable progress in recent time. In the impression of carved out fields of science, the Women Scientists are achieving worthwhile leading achievements with excellent work in the field of Materials Sciences, NanoSciences and Nanobiotechnology. The editors of Journal of Materials NanoScience have created a special issue to cover the diligent research being conducted by women researchers in India/Indian-abroad in materials science, nanoscience, nanobiotechnology, and related smart materials fields.

The Women Scientists from India/Indian-abroad are invited to publish their research in this special issue towards a perfect collection of reflection of research advances by women researchers in the following fields
* Materials Sciences * NanoScience * Nanotechnology * Nanobiotechnology * Polymer Science * Solar Energy Materials * Smart Chip Materials * Sensors * Energy Storage Materials * Materials Chemistry * Chemistry Nanomaterials * Nanocatalysis * Biomaterials and Nanobiomaterials * Biomedical Engineering Advances * and All allied fundamental to applied field advances.

The first author and/or corresponding author must be women.

Benefits

  • Open Access : all articles published in this issue will be available freely for download, reading and distribution.
  • No publication charges, No article processing charges, no any other charges of any kind for authors (Platinum open access)
  • The expert fast processing and publishing by the editors.
  • The photograph of first/corresponding author on front cover page on the printed journal issue.
  • Free print copy of the journal to all the corresponding authors.

(An opportunity for recognized research publication, collective information, and possible collaborations in research field)

How to Submit

Prepare your manuscript as per the author guidelines provided for the journal and submit the manuscript online on journal site http://thesciencein.org/journal/index.php/jmns/ (in the cover letter mention for consideration of article for special issue)

Submission Date: Submission ongoing
Issue compilation: by 30th April 2021.

Issue Editors

Dr. Bimlesh Lochab
Department of Chemistry, Research Block,
School of Natural Sciences, Shiv Nadar University
Tehsil Dadri, UP 201314, India
Dr. Pratima Solanki
Special Centre for Nano Sciences (SCNS)
Jawaharlal Nehru University, (JNU) New Delhi- 110067. India.

http://thesciencein.org/journal/index.php/jmns

In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins

urn:nbn:sciencein.cbl.2020v7.101

In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins

Published in: Chemical Biology Letters

Authors

  • Vaishali Chandel Amity University
  • Mitul Srivastava Translational Health Science and Technology Institute
  • Ashutosh Srivastava Amity University
  • Shailendra Asthana Translational Health Science and Technology Institute
  • Dhruv Kumar Amity University Uttar Pradesh, Noida

Keywords: Phytochemicals, Oncoproteins, Molecular docking, Molecular dynamics, simulations

Abstract

Cancer is the leading cause of mortality worldwide. Conventional chemotherapeutic agents pose a drawback as they are nonspecific. There is an urgent need to identify and design novel targets specific to the tumor. Almost 90,000 species of plants are used as a source of medicines to treat the majority of the disease including cancer. The objective of this study was to understand the interactions between the active phytochemicals selected on the basis of literature review and target oncoproteins in order to find out the biomolecules having strongest bonding actions. Molecular Docking of c-MYC, EGFR and ERBB2 with the selected Phytochemicals showed highest binding energy -7.8 Kcal/mol of EGCG with c-MYC, -8.7 Kcal/mol of Curcumin with EGFR, and -9.4 Kcal/mol of Quercetin with ERBB2. Moreover, molecular dynamics simulation data showed all three phytochemicals exhibits strong stability on their respective targets. Our studies reveal that these three phytochemicals could be promising candidates in designing and optimizing therapeutic strategies against cancer.

molecular modeling of plant drugs

Cite as:

Chandel, V., Srivastava, M., Srivastava, A., Asthana, S., & Kumar, D. (2020). In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins. Chemical Biology Letters, 7(1), 47-54.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/101

Nanobiotechnology and Biomaterials in Nuclear Medicine – special issue

Nuclear Medicine, a medical specialty involving the application of radioactive substances and magnetic materials in the diagnosis and treatment of disease have been highly successful in diagnosis of difficult to detect diseases and therapy of various dreaded diseases. Recently, there have been a tremendous research progress in development of newer methods, conjugates and pharmaceuticals for diagnosis and therapy using nanomaterials and nanomedicine approaches in radioactive materials.

The purpose of this special issue proposal is to summarize the recent advances in the field of new NanoMedicinal and Nanobiotechnological advances in development of probes and materials for potential molecular targets and understanding of their mechanism of actions, new radioconjugates development using nanobiomaterials, clinical evaluation and application of new Nano-radiopharmaceuticals, and new techniques/therapy development using Biomaterials. Recent progress will be covered through research articles, review articles and short communications.

The subtopics to be covered in this issue are (though not limited to):

– NanoChemistry of new radioactive elements.
– Organic chemistry of Nano-radiopharmaceuticals, chelating agents and standalone Nano-radiopharmaceuticals.
– Progress in SPECT using Nanobiomaterials.
– Progress in Nano-Positron Emission Tomography (nanoPET).
– Application of nanoscience and nanotechnology to Nuclear Medicine.
– Identification of new therapeutic targets.
– Treatment advances of various diseases – cancer, infections, inflammations etc using nano-radiopharmaceuticals.
– Clinical studies and evaluation of nano-radiopharmaceuticals.
– Malarial/mycobacterial/microbial/viral diagnosis and therapy development using nano(bio)materials including biochemical aspects of nano-biomaterials.
– Therapeutic and diagnostic applications of new nano and biomaterials.
– New therapeutic policies and emerging targets for Nuclear nanoMedicine.
– New approaches adopted for the development of nanomedicine of new radiodiagnostic and radiotherapeutic molecules.
– Rational design and drug discovery-Structure-activity relationship (SAR).
– NanoDrug Delivery of radiopharmaceuticals – application of different nanobiotechnology conjugates and systems in radiopharmaceuticals.
– Synthetic strategies of new radioactive conjugate molecules.
– Molecular self-assembly as drug delivery carriers of radiopharmaceuticals – Nanotechnology and Biotechnology.
– Environmental aspects, safety measures advances in nuclear medicine.

Provisional Schedule:

Manuscript submission: Submission open and ongoing now.
Issue Completion: August 2020.

Editors:

Dr. Anil Mishra
Dr. Anil Kumar Mishra
Scientist ‘G’ and Add Director,
Institute of Nuclear Medicine and Allied Science,
DRDO, Timarpur, Delhi. India
Dr. B.S. Chhikara,
University of Delhi
email: drbs @ aditi. du.ac.in

Nuclear and Nano-Medicine researchers are invited to submit their research / review article for this special issue. Manuscript should be prepared and submitted as per author guidelines provided on journal site.

Important Links:

Author Guidelines for preparation of manuscript:

Manuscript template (download): Download template MS word 2007-2010, Citation manager style files and other details are provided in author guidelines section on journal site.

http://thesciencein.org/author-guidelines-for-journal-of-nanomedicine section -nanomaterials-materials-nanoscience/

Manuscript Submission: Authors need to submit their manuscript on http://thesciencein.org/journal/index.php/jmns/about/submissions OR http://pubs.iscience.in/journal/index.php/cbl/about/submissions (India-regional site).

There is no fees for publication in special issue or journal.

urn:nbn:sciencein.jmns.2020.v7.99

Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review

  • Parul Pant

    University of Delhi

  • Dr. Chetna Gupta

    University of Delhi

  • Sagar Kumar

    Indian Institute of Science

  • Apoorva Grewal

    University of Delhi

  • Shivani Garg

    University of Delhi

  • Aishwarya Rai

    University of Delhi

Keywords:

Silica, Nanoparticles,
trumeric, drug delivery, cancer,
diabetes, nanomedicine, biomedical science

Abstract

Silica nanoparticles offer a promising platform for the delivery of drugs, in particular for the drugs which lack water solubility, target capability and have non-specific distribution, systematic toxicity and low therapeutic index. In this review, we focus on the synthesis and therapeutic (particularly, anti-cancer) applications of Curcumin loaded Silica Nanoparticles. Various surface modifications of silica nanoparticles have been discussed that are used to enhance their therapeutic applications. The characterization techniques and study of their biocompatibility have also been presented.

Cite as: Pant, P., Gupta , C., Kumar, S., Grewal, A., Garg, S., & Rai, A. (2020). Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review. Journal of Materials NanoScience, 7(1), 1-18.

Full text at http://thesciencein.org/journal/index.php/jmns/article/view/99 and

Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics

Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics

urn:nbn:sciencein.cbl.2020v7.103

A review on Corona Virus Disease COVID-19, epidemiology, prevention, and anticipated therapeutic advances

Published in Chemical Biology Letters

  • Bhupender S. Chhikara University of Delhi
  • Brijesh Rathi University of Delhi
  • Jyoti Singh M.D. University
  • Poonam University of Delhi

Keywords: New Virus, SARS-Cov-2, Corona Virus, Pharmaceuticals, Medicinal Chemistry, Diagnosis, Chemical Drugs, Epidemiology, Cell Mechanism, Anti-viral drugs, Antibody Therapy, Pharmacology

Abstract

The recent outbreak of Corona virus SARS-CoV-2 disease COVID-19 in the China and subsequent intermittent spread of infection to other countries has alarmed the medical and scientific community mainly because of lethal nature of this infection. Being a new virus in the category, the immediate emergency therapy is not available for the treatment of this disease, leading to widespread fear of infection and has created social issues for infected peoples. Herein, the epidemiology of COVID-19 infection, transmission characteristics of SARS-CoV-2 virus spread, effectiveness of preventive measures, coronavirus family, structural characteristics of virus, current literature advances for the diagnostics development (RT-PCR, CT-Scan, Elisa) and possible drug development based virus life cycle (Entry inhibitors, replication inhibitors, nucleoside, nucleotide, protease inhibitors, heterocyclic drugs, including biological therapeutics (monoclonal antibodies therapy, vaccine development) and herbal formulations have been reviewed. The chemical drug molecules with prospective application in the treatment of COVID-19 have been included in the discussion.

COVID-19 infections drugs review

Cite as: Chhikara, B. S., Rathi, B., Singh, J., & Poonam (2020). Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics: A review on Corona Virus Disease COVID-19, epidemiology, prevention, and anticipated therapeutic advances. Chemical Biology Letters, 7(1), 63-72.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/103

This is open access article published as part of priority information sharing for emergency infection COVID-19 (CBL journal confirmed its association for the priority availability of articles related with COVID-19 infection with Open Access (The Wellcome Trust, U.K. signatories).

Readers may share this article to colleagues, via email, facebook, linkedin, researchgate networks.

Anti-microbial and anti-tumor studies of newly synthesized 2-(4-morpholinyl)-4,6-diarylpyrimidines using nanosized NiO catalytic framework

urn:nbn:sciencein.cbl.2020v7.104

Anti-microbial and anti-tumor studies of newly synthesized 2-(4-morpholinyl)-4,6-diarylpyrimidines using nanosized NiO catalytic framework

Published in Chemical Biology Letters

  • Priyanka Khyaliya

    Mody University of Science and Technology

  • Ahanthem Priyanca Devi

    Mody University of Science and Technology

  • Sudesh Kumar

    Banasthali Vidyapith

  • Ravi Kant

    Shri Ramswaroop Memorial University

  • Keshav Lalit Ameta

    Mody University of Science and Technology

Keywords:

NiO nanocatalyst, Pyrimidines,
Chalcones, Anti-microbial, Anti-tumor

Abstract

A convenient and cost-effective methodology has been developed for the synthesis of some 2-substituted-4,6- diarylpyrimidines through one-pot conversion of various substituted chalcones, S-benzylthiouronium chloride (SBT) and morpholine using NiO nanoparticles as a reusable and economic catalyst. The deployment of this catalyst empowers the synthesis of variety of 2-(4- morpholinyl)-4,6-diarylpyrimidines in improved yields with easy work-up in a relatively short reaction time. The synthesized compounds have been studied for their potential anti-microbial and anti-tumor activities.

Cite as: Khyaliya, P., Devi, A. P., Kumar, S., Kant, R., & Ameta, K. L. (2020). Anti-microbial and anti-tumor studies of newly synthesized 2-(4-morpholinyl)-4,6-diarylpyrimidines using nanosized NiO catalytic framework. Chemical Biology Letters, 7(1), 55-62.

Full text: http://thesciencein.org/journal/index.php/cbl/article/view/104 and http://pubs.iscience.in/journal/index.php/cbl/article/view/972

Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases

Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases

URN:NBN:sciencein.cbl.2020.v7.102

Published in Chemical Biology Letters

Anti cancer mechanism of Ziziphus jujube Ber extract

  • Radhakrishna G Pillai

    University of Calicut

Keywords:

cancer, proapoptotic genes,
phytochemical, diet, HEK293,
phytomedicine, anti-cancer nutrients, herbal
drugs

Abstract

Severe side effects as well as the cost of chemotherapy necessitate the need for alternative therapies. Use of plant derived drugs is on the increase for the treatment of various diseases including cancer. This study was designed to explore the effects of the aqueous extract of the ripe fruits of Ziziphus jujube on MCF-7, HCT116 and HEK 293 cell lines to examine the possibility of it being developed as a therapeutic aid in cancer treatment. Cells were exposed to different doses (0-2mg/ml) of the aqueous extract for different time durations ranging from 24h to 72hr. Cell viability and the change in expression of various apoptosis related genes such as Bcl2, Bax, caspase-3 and caspase-9 were studied. Rate of proliferation of the cancer cells (MCF-7 and HCT116) decreased on exposure to the extract in a time and concentration dependent manner. Expression levels of all the genes studied, except Bcl2, showed an increase. Bcl2 expression was inversely proportional to time and concentration of the extract. Levels of activated caspases 3 and 9 were also increased. This report points to the possibility of developing the extract of Ziziphus jujube as a drug for the treatment of cancer.

How to Cite Pillai, R. G. (2020). Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases: Anti cancer mechanism of Ziziphus jujube Ber extract. Chemical Biology Letters, 7(1), 41-46.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/102 and/or http://pubs.iscience.in/journal/index.php/cbl/article/view/948

Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents

Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents

urn:nbn:sciencein.cbl.2020v7.100

Published in Chemical Biology Letters

  • Nidhi Singh

    Amity University Uttar Pradesh

  • Shridhar Satpute

    Dr. Ambedkar College

  • Naveen Polkam

    Jawaharlal Nehru Technological University

  • Ravi Kant

    Shri Ramswaroop Memorial University

  • Jaya Shree Anireddy

    Jawaharlal Nehru Technological University

  • Deepa Panhekar

    Dr. Ambedkar College

  • Jaya Pandey

    Amity University Uttar Pradesh

Keywords:

4H-chromen-4-one, Oxidative Michael
addition, in-silico analysis, drug likeness
score, Molecular modelling, chromones

Abstract

A library of 28 newer 4H-chromen-4-one derivatives were designed, synthesized and screened for their antibacterial and antifungal efficacy against a panel of bacterial and fungal causative species. Fries and oxa-Michael protocols were employed to achieve the target compound. From the assayed, compounds 5c, 5e, 6a, 7b, 7d, 9a and 9b demonstrated promising anti-bacterial profile whereas products 6a, 7b, 8b and 9c elicited excellent anti-fungal properties. Further, in silico molecular properties were predicted for these sketched analogues to assess their bio availability and drug likeness by using molinspiration software/toolkit. None of them violated Lipinski’s rule of five, signifying them as better anti-bacterial and anti-fungal agents. Both in-silico and biological studies predict derivative 6a and 7b as best agent.

Chromene derivatives as antifungal agents

Cite as: Singh, N., Satpute, S., Polkam, N., Kant, R., Anireddy, J. S., Panhekar, D., & Pandey, J. (2020). Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents. Chemical Biology Letters, 7(1), 27-40.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/100 and http://www.pubs.iscience.in/journal/index.php/cbl/article/view/959