urn:nbn:sciencein.cbl.2019.v6.115
Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice
Published in: Chemical Biology Letters
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Suman Devi
Maharshi Dayanand University
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Jagjeet Singh
Maharshi Dayanand University
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Vijay Kumar
Maharshi Dayanand University
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Vinay Malik
Maharshi Dayanand University
Keywords:
histopathology, oxidative stress,
kidney, lipid peroxidation, toxicology
Abstract
The present study investigated the effect of monocrotophos, a commonly used organophosphate pesticide exposure in the kidney tissues of the swiss albino mice. Monocrotophos was administered at the sub-lethal doses of 1.25mg/kg, 2.5 mg/kg and 5.0 mg/kg body weight for 24 hr. Monocrotophos toxicity generated oxidative stress in the mice as evidenced by significant decrease in the activities of glutathione, superoxide dismutase and catalase enzymes. The exposure increased the lipid peroxidation and protein oxidation in a dose dependent manner. Oxidative stress generation also elicited cytotoxic effects on the mice kidney which were supported by the histopathological changes like degeneration in glomerulus, bowmen’s capsule and tubules, hemorrhage, mononuclear cell infiltration, tubular cast and congested blood vessels in a dose-dependent manner. In conclusion, the study indicated that monocrotophos exposure at various doses induces significant deleterious health effects in mice kidney tissues via oxidative stress generation.
Cite as: Devi, S., Singh, J., Kumar, V., & Malik, V. (2019). Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice. Chemical Biology Letters, 6(2), 39-45.
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