Author: 9853121882ya

In the current scenario, Deep Eutectic Solvents (DESs) are persuasive greener solvents for the successful synthesis of different nanostructures due to their tunable properties with enhanced applications. We report here the successful formation of a nanocomposite based on cellulose and magnetite nanoparticles. The method of isolating cellulose from fruit shells of Limonia acidissima (L.) as detailed in the work is described for the first time. Magnetite nanoparticles were synthesized through the cost effective co-precipitation method and DES embracing choline chloride and fructose were used as non-toxic dispersant for the synthesis of cellulose-magnetite nanocomposite. Various physiochemical parameters like compositional, structural, morphological and magnetic properties are analyzed using FTIR, XRD, HRTEM, SAED and VSM techniques. Anticancer and antitubercular activities, performed by MTT and LRP assays respectively, reveals that the IC₅₀ values for cellulose, magnetite and cellulose-magnetite nanocomposite are found to be 20.65 µg/ml, 44.66 µg/ml and 8.685 µg/ml and cellulose-magnetite nanocomposite shows 51.95% inhibition at 200 µg/ml concentration against Mycobacterium tuberculosis. The obtained results suggest that the prepared cellulose-magnetite nanocomposite can serve as a potential candidate for drug designing with the use of green solvents.

Authors: Swathi Pon Sakthi Sri. V, Mary George

Published in: Journal of Materials NanoScience

Link: http://pubs.thesciencein.org/journal/index.php/jmns/article/view/188

Biosynthesis of the metallic nanoparticle is gaining importance because it is a single-step process, nontoxic, environmentally acceptable, and easily scaled up. The present study investigated the biosynthesis of silver nanoparticles (AgNPs) via reacting olive wastewater filtrate (OWF) with silver nitrate, and the formation of AgNPs was confirmed by a color change of the reaction mixture and visible spectrophotometry. Additionally, the influence of pH, reaction time, AgNO₃ concentration, temperature, and OWF volume on the proposed method was investigated. It was found that with increasing the mentioned parameters, the formation of the AgNPs was increased under the experimental conditions. The results showed that OWF represented a promising material for the biosynthesis of AgNPs.

Authors: Abdounasser Albasher Omar, Nawal Abdurazq Ahmad, Mawada Moftah Rajab, Nour Elhoda Berrisha, Amani Almabrouk Alnakkaa, Bushra Adel Alshareef, Rana Rajab Qadmour 

Published in Journal of Materials NanoScience

Link: http://pubs.thesciencein.org/journal/index.php/jmns/article/view/243

Published in: Chemical Biology Letters

Link: http://pubs.thesciencein.org/journal/index.php/cbl/article/view/127

Five member heterocyclic 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. The important mechanism behind tumor suppression by 1,3,4-Oxadiazole is related with the inhibition of different growth factors, enzymes and kinases etc. The 1,3,4-Oxadiazole scaffold is a five member heterocyclic ring having versatile activities and created interest for synthetic organic and medicinal chemists for the designing of novel compounds having anti- cancer activity. There are great potential in the development of the simple and small 1,3,4-oxadiazole nucleus which is present in various compounds that possess considerable pharmcological properties such as anticancer and aimed to evaluate new products. The main aim of this review article is to highlight the targeted activity of 1,3,4-Oxadiazole derivatives and their structure activity relationship to generate potential anticancer agents.

Published in: Chemical Biology Letters