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Organic Chemistry Letters

Organic Chemistry Letters

The Organic Chemistry Letters (OCL) is an international journal meant to provide a rapid forum for publication of quality original research from organic chemistry. Organic Chemistry Letters covers the scientific ideas and approaches of synthetic organic chemistry, catalysis, new methodologies, natural product synthesis, new reaction pathways, peptide synthesis, small molecule synthesis, organic molecules, chemical technology and other allied areas covering organic chemistry. OCL covers the fundamental research in all branches of the theory and practice of organic chemistry for the better understanding of organic chemistry phenomenon at molecular level. The journal welcomes original research contribution from the community of organic chemists.

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Recent ArticlesAbout JournalAuthor GuidelinesSubmit ManuscriptContact Us

Recent Article

2014 – Volume 1, Issue 1

Potassium Decatungstate Catalyzed Condensation of Indoles with Acetone
Suresh Kumar, Radheshyam Mona and V. Ramarao
Org. Chem. Lett., 2014, 1(1), 15-21 pdfSubscription Access

Abstract
Reaction of different substituted indoles with acetone have been investigated using Potassium decatungstate as catalyst. An efficient protocol has been developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes by the reaction of indole with acetone under different reaction conditions. The reaction conditions are benign, require shorter reaction time and gave good yields.


Design and Evaluation of Multifunctional Fatty Acyl and peptide derivatives of Anti-HIV Nucleosides as Microbicidal Agents
Bhanu P. Venkata and Arun P. Murthy
Org. Chem. Lett., 2014, 1(1), 22-34 pdfSubscription access

Abstract
The conjugation of nucleosides to the polyarginine-fatty acyl residues is investigated to generate microbicides and circumvent the problems associated with using parent anti-HIV nucleosides. The combination results in development of microbicides having enhanced efficacy, longer duration of action by sustained intracellular release of active substrates at adequate concentrations, and/or higher uptake into infected cells. The combination of compounds reduces the toxicity associated with nucleosides. Furthermore, development of viral resistance to two or more active drugs would occur at lower rate than to either compound alone.


Synthesis and evaluation of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates as antifungal agents
Rubel Chakravarty and Prasenjit Mohato
Org. Chem. Lett., 2014, 1(1), 35-46 pdfSubscription access

Abstract
A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for their fungicidal properties. Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of fungal growth with an IC50 value of 5.6 µM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the fungal proliferation by 73% and 48%, respectively, at a concentration of 50 µM.


The Journal ‘Organic Chemistry Letters’ publishes research article, reviews, mini-reviews and short communications from Organic Chemistry.

Please see author guidelines at http://pubs.iscience.in/journal/index.php/ocl

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Integrated Science Publishing
Delhi-110081
email: pubs@iscience.in

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Chemical Biology Letters

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Chemical Biology Letters
Editors
Prof. Keykavous Parang
Chapman University Editor (USA)
Dr. B.S. Chhikara,
University of Rhode Island Executive Managing Editor
Dr. R. Dabur,
M.D. University Associate Editor (India)

ISSN 2347–9825

Chemical Biology Letters is now indexed in WHO’s HINARI (see details at Chemical Biology Letters on HINARI ).

The Chemical Biology Letter is an international journal that provides a rapid forum for publication of quality original research at the interface of chemistry and biology. Chemical biology letters covers the scientific ideas and approaches of chemistry, biology and allied interdisciplinary areas such as medicinal chemistry, drug discovery, drug delivery, biosensor, protein chemistry, biological chemistry, biomolecules, bio-technology, biomedical, molecular biology and other allied areas covering chemistry and biology for better understanding of biological phenomenon at molecular level. The journal invite research articles from the community of chemical biologists.
See Five selected articles in Medicinal Chemistry / Biomedical Sciences

 

Recent Aricle
Latest Articles
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In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, [...]
Source: Chem Biol Lett
In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also [...]
Source: Chem Biol Lett
A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H- benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. Structures have been confirmed by spectroscopic analysis. All the newly [...]
Source: Chem Biol Lett
A new class of 1,3,4-thiadiazole derivatives 8a-i incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties were synthesized by the reaction of arylidene derivatives of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety (Schiff base) 7a-i with thioglycolic acid. Schiff base 7a-i were synthesized by the reaction of 1,3,4-thiadiazoles 2-amine having imidazo [...]
Source: Chem Biol Lett
Antibiotic resistant bacteria (ABR) is an alarming issue and it has to be eliminated before enter into the environment. The role of efflux pump inhibitor, reserpine – a plant alkaloid in reducing the antibiotic resistance in Staphylococcus sp., Streptococcus sp. and Micrococcus sp. from poultry litter were evaluated. [...]
Source: Chem Biol Lett
A new series of N-(6-methoxybenzo[d]thiazol-2-yl)-2-substituted phenyl-1H-benz[d]imidazole-1-carbothioamide derivatives (5a-5h) has been synthesized and evaluated for antibacterial, antifungal and antimalarial effects. All these compounds were characterized and screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Titled compounds were also evaluated for their antimalarial activity against P. falciparum. [...]
Source: Chem Biol Lett
Plants produce an enormous number of phytochemicals as a part of their primary as well as secondary metabolism of those many could be of therapeutic value especially antimicrobial application to human beings. Majority of the isolated antimicrobials pertain to chemical groups namely, phenolics, terpenes, alkaloids and polypeptides, and exhibit multiple [...]
Source: Chem Biol Lett
The Swine influenza is a highly contagious respiratory disease caused by one of several swine influenza A viruses. The viral replication complex of H1N1, formed by three proteins PA, PB1 and PB2, plays a major role in host adaptation and subsequent infection. The conserved interaction sites of these three proteins [...]
Source: Chem Biol Lett
Outer membrane proteins (OMPs) are distinctive features of Gram-negative bacteria. Apart from their structural role, they play a crucial role in host pathogen interaction, virulence and pathogenesis of bacteria. Upon interaction with the host immune cells, OMPs stimulate production of proinflammatory molecules that may result in an uncontrolled inflammation, leading [...]
Source: Chem Biol Lett
An outburst of Ebola Hemorrhagic Fever (EHF) in recent years is a challenge towards health preparedness of India. Oseltamivir is the only frontline drug used in the treatment of Ebola hemorrhagic fever. In order to enhance preparedness again Ebola virus induced fever it is required to identify more derivatives with [...]
Source: Chem Biol Lett

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