Organic Chemistry Letters

Organic Chemistry Letters

The Organic Chemistry Letters (OCL) is an international journal meant to provide a rapid forum for publication of quality original research from organic chemistry. Organic Chemistry Letters covers the scientific ideas and approaches of synthetic organic chemistry, catalysis, new methodologies, natural product synthesis, new reaction pathways, peptide synthesis, small molecule synthesis, organic molecules, chemical technology and other allied areas covering organic chemistry. OCL covers the fundamental research in all branches of the theory and practice of organic chemistry for the better understanding of organic chemistry phenomenon at molecular level. The journal welcomes original research contribution from the community of organic chemists.

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Recent Article

2014 – Volume 1, Issue 1

Potassium Decatungstate Catalyzed Condensation of Indoles with Acetone
Suresh Kumar, Radheshyam Mona and V. Ramarao
Org. Chem. Lett., 2014, 1(1), 15-21 pdfSubscription Access

Abstract
Reaction of different substituted indoles with acetone have been investigated using Potassium decatungstate as catalyst. An efficient protocol has been developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes by the reaction of indole with acetone under different reaction conditions. The reaction conditions are benign, require shorter reaction time and gave good yields.


Design and Evaluation of Multifunctional Fatty Acyl and peptide derivatives of Anti-HIV Nucleosides as Microbicidal Agents
Bhanu P. Venkata and Arun P. Murthy
Org. Chem. Lett., 2014, 1(1), 22-34 pdfSubscription access

Abstract
The conjugation of nucleosides to the polyarginine-fatty acyl residues is investigated to generate microbicides and circumvent the problems associated with using parent anti-HIV nucleosides. The combination results in development of microbicides having enhanced efficacy, longer duration of action by sustained intracellular release of active substrates at adequate concentrations, and/or higher uptake into infected cells. The combination of compounds reduces the toxicity associated with nucleosides. Furthermore, development of viral resistance to two or more active drugs would occur at lower rate than to either compound alone.


Synthesis and evaluation of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates as antifungal agents
Rubel Chakravarty and Prasenjit Mohato
Org. Chem. Lett., 2014, 1(1), 35-46 pdfSubscription access

Abstract
A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for their fungicidal properties. Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of fungal growth with an IC50 value of 5.6 µM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the fungal proliferation by 73% and 48%, respectively, at a concentration of 50 µM.


The Journal ‘Organic Chemistry Letters’ publishes research article, reviews, mini-reviews and short communications from Organic Chemistry.

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