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Editors
Prof. Keykavous Parang
Chapman University Editor (USA)
Dr. B.S. Chhikara,
University of Rhode Island Executive Managing Editor
Dr. R. Dabur,
M.D. University Associate Editor (India)
ISSN 2347–9825
Chemical Biology Letters is now indexed in WHO’s HINARI (see details at Chemical Biology Letters on HINARI ).
The Chemical Biology Letter is an international journal that provides a rapid forum for publication of quality original research at the interface of chemistry and biology. Chemical biology letters covers the scientific ideas and approaches of chemistry, biology and allied interdisciplinary areas such as medicinal chemistry, drug discovery, drug delivery, biosensor, protein chemistry, biological chemistry, biomolecules, bio-technology, biomedical, molecular biology and other allied areas covering chemistry and biology for better understanding of biological phenomenon at molecular level. The journal invite research articles from the community of chemical biologists.
See Five selected articles in Medicinal Chemistry / Biomedical Sciences
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Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (15a-15t) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut [...]
Source: Chem Biol Lett The current concepts of cancer therapy are moving towards personalized treatment regimen aiming to reduce toxicity and improve efficacy of therapeutic agents. With the development of molecular imaging and targeted therapies personalized care has received a shot in the arm. However, these developments are not without challenges. Drug delivery, metabolism, [...]
Source: Chem Biol Lett Hyperparathyroidism (HPTH) is a condition in which the level of parathyroid hormone in blood is raised. Gold standard for the diagnosis of HPTH is a measurement of serum parathyroid hormone levels, accompanied by testing serum calcium levels, to differentiate between primary and secondary HPTH. The first line of treatment with [...]
Source: Chem Biol Lett In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, [...]
Source: Chem Biol Lett In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also [...]
Source: Chem Biol Lett A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H- benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. Structures have been confirmed by spectroscopic analysis. All the newly [...]
Source: Chem Biol Lett A new class of 1,3,4-thiadiazole derivatives 8a-i incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties were synthesized by the reaction of arylidene derivatives of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety (Schiff base) 7a-i with thioglycolic acid. Schiff base 7a-i were synthesized by the reaction of 1,3,4-thiadiazoles 2-amine having imidazo [...]
Source: Chem Biol Lett Antibiotic resistant bacteria (ABR) is an alarming issue and it has to be eliminated before enter into the environment. The role of efflux pump inhibitor, reserpine – a plant alkaloid in reducing the antibiotic resistance in Staphylococcus sp., Streptococcus sp. and Micrococcus sp. from poultry litter were evaluated. [...]
Source: Chem Biol Lett A new series of N-(6-methoxybenzo[d]thiazol-2-yl)-2-substituted phenyl-1H-benz[d]imidazole-1-carbothioamide derivatives (5a-5h) has been synthesized and evaluated for antibacterial, antifungal and antimalarial effects. All these compounds were characterized and screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Titled compounds were also evaluated for their antimalarial activity against P. falciparum. [...]
Source: Chem Biol Lett Related Journals
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