Antiproliferative effect of Mosinone-A on expression of apoptotic and cell cycle associated proteins in DMBA induced hamster buccal pouch carcinogenesis – retraction note

Antiproliferative effect of Mosinone-A on expression of apoptotic and cell cycle associated proteins in DMBA induced hamster buccal pouch carcinogenesis

Submitted to: Chemical Biology Letters

Sugunadevi Govindasamy1, Anbu Singaravelu2 and Suresh Kathiresan3

1Assistant Professor, Department of Biochemistry, Dhanalakshmi Srinivasan College of Arts & Science for Women (Autonomous), Perambalur -621212 2Assistant Professor, Department of Biochemistry, Sacred heart college (Autonomous), Thirupattur -635 601 3Associate Professor, Department of Biochemistry& Biotechnology, Annamalai University, Annamalai Nagar.

Abstract

The present study aimed to investigated the antiproliferative potential of Mosinone-A on cell proliferation, apoptosis and cell cycle proteins during 7, 12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch (HBP) carcinogenesis. A total number of 40 golden Syrian hamsters were randomized into 4 groups of 10 animals in each. Group I animals were served as untreated control. Groups II and III animals were painted with 0.5% DMBA in liquid paraffin three times per week for 14 weeks on the left buccal pouches. Group III animals were orally administered with Mosinone-A (2 mg kg-1 b.wt) starting one week before the exposure to the carcinogen and continued on days alternate to DMBA painting, until the sacrification of the animals. Groups IV animals were received Mosinone-A alone throughout the experimental period. Topical application of DMBA for 14 weeks induced buccal pouch carcinomas associated with increased expression of Cox-2, P21, iNos and SIAT1 whereas decreased expression of Bax, Cleaved caspase-9, P12DOC-1, p16INK4A and p15INK4B. Oral administration of Mosinone-A significantly inhibited the development of HBP carcinomas as revealed by decreased expression of Cox-2, P21, iNos and  SIAT1 and over expression  Bax, Cleaved caspase-9, P12DOC-1, p16INK4A and  p15INK4B. The result of the present study indicates that Mosinone-A can exerts protective effects against DMBA induced buccal pouch carcinogenesis by inhibiting cell proliferation and inducing differentiation and apoptosis.

Key words: Oral cancer; Mosinone-A; DMBA; hamster; carcinogenesis; apoptosis

Note: this manuscript has been removed from journal due to ‘no response from authors’. It was reviewed and accepted by editor for consideration in Chemical Biology Letters, however, authors did not respond to emails and reminders for required revisions and submission of revised/updated manuscript.

Proceedings of National Conference on Recent Advances in Chemical Sciences towards Green and Sustainable Environment 2017: RACSGSE-SBAP

2017: RACSGSE-SBAP

Proceedings ISBN: 978-93-5311-552-4

UGC funded National Conference on Recent Advances in Chemical Sciences towards Green and Sustainable Environment – Swachh Bharat Abhiyaan Perspective RACSGSE-SBAP 2017

Organized by

Department of Chemistry
Aditi Mahavidyalaya
University of Delhi
Delhi, India

Table of Contents

Articles

Summary Report of National Conference RACSGSE-SBAP 2017 Bhupender Singh PDF 1-6
Creating Environmental Awareness among Children: Swachh Bharat Mission Perspective Manisha Wadhwa nee Dabas PDF 7-16
Decentralization of solid wastes: a sustainable step towards Swachh Bharat Abhiyan Suruchi Suruchi, Savita Bargujar PDF 17-20
Sustainable development – its goal and strategies Poonam Lakra PDF 21-28
Renewable energy scenario in India – Scope and challenges Shikha Yadav PDF 29-34
Heavy metals and sewage toxicity impact on seed germination, plant growth and yield of Pigeon Pea Jyoti Singh PDF 35-38
Nanotechnology approach towards green and sustainable environment Shashi Prabha PDF 39-44
Organic Light Emitting Diode: Energy efficient material for sustainable green environment Tanya Dhawan, Aarti Aarti, Astha Kotnala, Bhupender S. Chhikara PDF 45-56
Management of e – waste in India: A Swachh Bharat Abhiyaan perspective Mamta Sharma, Sandeep Sharma, Parul Chopra PDF 57-60
Trash to treasure: processing the solid waste in useful manner Saloni Nischal, Indu Nashier Gahlawat PDF 61-70
Global warming: Causes and Effects Varsha Sharma, Indu Nashier Gahlawat PDF 71-74
Threat inside house -Indoor pollution Asha Asha, Indu Nashier Gahlawat PDF 75-78

Reproductive Inflammatory Mediators and Male Infertility – Special issue Chemical Biology Letters

Association between male reproductive tract infection and inflammation with male infertility is an extremely debated topic in the arena of Andrology research. Disruption of semen quality in cases of testicular and accessory gland infections, owe to altered spermatogenesis, sperm maturation and/or transport. The impact depends on the intensity, duration of progression, mediators of the inflammatory process and individual susceptibility to the infection. Interactions among the mediators with immunological cells and other regulators affect sperm function and have been reported to be associated with male infertility. However, the issue is still under debate and paves several dimensions of research in this realm.

This special issue aims to summarize the current knowledge on male reproductive tract inflammation and causative agents with its consequences on male reproductive functions. We believe that this issue will broaden the understanding of male reproductive immunology. These observations will definitely help to develop a new diagnostic stand for males suffering from gonadal tract infection and inflammation.

Potential topics include but are not limited to the following:

● Testicular infection and inflammation
● Accessory sex organ inflammation and male infertility
● Seminal infections and its markers
● Role of leukocytes in male reproductive tract inflammation
● Systemic diseases and immunomodulation in male infertility
● Management of male reproductive tract inflammation
● Roles of hormones and male reproductive immunology

Guest Editors:

Pallav Sengupta, PhD
Department of Physiology
Faculty of Medicine & Biomedical Sciences
MAHSA University
[pallav@mahsa.edu.my; pallav_cu@yahoo.com]
Sulagna Dutta, PhD
Department of Physiology
Faculty of Dentistry
MAHSA University
[duttasulagna@mahsa.edu.my; sulagna_dutta11@yahoo.com]

Submission

Article (Research articles and Review Articles) should be submitted online on the journal site http://www.pubs.iscience.in/journal/index.php/cbl as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

Submission Deadline (extended) 31st December 2019 . 15th January 2020
Publication Date 1st March 2020

There is no publication charges for publishing in special issue or in Chemical Biology Letters.

Phytomedicine Journal Special issue on Plant medicine | Biomedical and Therapeutic Sciences

Phytomedicine is plant based therapeutics development, a discipline of modern scientific analysis and application of traditional medicinal practices based on various plant materials in prevention and therapy of diseases. The special issue on phytomedicine covering recent advances on research in scientific advances on plant based medicine development span the subfields (though not limited to as phytomedicine is a very wide discipline):

  1. Ethnobotanical and Ethnomedicinal practices research advances
  2. Phytopharmaceutical analysis
  3. Active constituent identification and characterization
  4. New plant identification for different disease treatment
  5. Modern Ayurvedic practices
  6. Drug delivery methods for phytopharmaceuticals
  7. Extraction and Isolation Methods development

Editor:

Dr. Rambir Singh
HOD
Institute of Biomedical Sciences
Bundelkhand University, Jhansi, UP.

How to submit:

Research Article, Review Articles, Short Communication and Experts View on phytomedicine should be prepared as per author guidelines and submitted on the Journal website at http://www.pubs.iscience.in/journal/index.php/jbts/

Last date of submission: Ongoing Submission

Note: there is no publication charges for publishing in the special issue or in journal.

Recent Articles and Issue updates

Chemical Biology Letters Impact Factor and Indexing

Journal Name : Chemical Biology Letters
ISO 4 abbreviation Chem. Biol. Lett.
Publisher iScienceIN Publishing
Journal Issues per volume/year Two
Frequency Biannual
Editorial Board Members Multinational [Link]
Journal Type International
Journal International Serial Number – ISSN 2347–9825
Discipline Chemistry, Biology, Medicinal Chemistry,
Biochemistry, Drug Discovery, Drug Delivery,
Chemical Biology, Biotechnology
Demography of Authors Unites State, China, Africa, Japan,
Korea, Hong Kong, India [Link]
Start Year 2014
Language English
Article type Research Article, Review Article,
Short Communications, Editorial
Matrices
  • Articles Published#

    041

  • Total Citations* recorded

    172

  • Citation Factor 2018*

    4.195

  • Chemical Biology Letters on SCImago Journal & Country Rank

Journal Link: http://pubs.iscience.in/journals/cbl
http://thesciencein.org/cbl
Google Scholar Link: https://scholar.google.com/scholar?as_vis=1&q=source:Chemical+source:Biology+source:Letters&hl=en&as_sdt=1,5

#Citation Source: Google Scholar for IF (interim) Calculations. *Citation recorded as on 28-Dec-2018

Indexed in

Google Scholar Link: https://scholar.google.com/scholar?as_vis=1&q=source:Chemical+source:Biology+source:Letters&hl=en&as_sdt=1,5
Scopus Indexed in SCOPUS http://scopus.com
CBL SCOPUS link: https://www.scopus.com/sourceid/21100856757
WHO HINARI Link http://extranet.who.int/hinari/en/login_warning.php?jid=24627
Chemical Abstracts CAS Indexed in Chemical Abstract Service – American Chemical Society https://www.cas.org/
CODEN: CBLHA5
Link: Chemical Biology Letters – CAS source list
CBL content search in SciFinder indexed


Submit article in Chemical Biology Letters

Chemical Biology Letters

Journal of Materials NanoScience Impact Factor and Indexing

Journal Name : Journal of Materials NanoScience
ISO 4 abbreviation : J. Mat. NanoSci.
Publisher iScienceIN Publishing
Journal Issues per volume/year Two
Frequency Biannual
Editorial Board Members Multinational [Link]
Journal Type International
Journal International Serial Number – ISSN 2394-0867
Discipline NanoChemistry, Nanomaterials, NanoScience, Nanotechnology, Nanocatalysis, NanoChips, NanoSensors, NanoEngineering, NanoMedicine, NanoBiotechnology, NanoDrug Delivery
Demography of Authors Global: Unites State (USA), United Kingdom (UK), Africa, Japan,
Korea, Hong Kong, India [Link]
Start Year 2014
Language English
Article type Research Article, Review Article,
Short Communications, Editorial
Matrices
  • Articles Published#

    022

  • Total Citations* recorded

    122

  • Citation Factor 2018*

    5.545

Journal Link: http://pubs.iscience.in/journals/jmns
http://thesciencein.org/journal/index.php/jmns

#Citation Source: Google Scholar for IF (interim) Calculations. *Citation recorded as on 21-Dec-2018

Indexed in

Google Scholar Link: J Materials NanoScience on Google Scholar
WHO HINARI Link http://extranet.who.int/hinari/en/login_warning.php?jid=43858
CAS Under review for Indexing http://CAS.org
Scopus Under review for Indexing http://scopus.com


Submit article in JMNS

Integrated Environmental Science : BS Chhikara | ScienceIn Publishing

Book: Integrated Environmental Science

Author: BS Chhikara


Purchase this book : Contact us through contactus page.

Table of Content

Unit 1: Introduction to environmental studies

  • Multidisciplinary nature of environmental studies
  • Scope and Importance; Need for public awareness.

Unit 2:  Ecosystems

  • What is an ecosystem? Structure and function of ecosystem; Energy flow in an ecosystem: food chains, food webs and ecological succession. Case studies of the following ecosystems:
  • Forest ecosystem
  • Grassland ecosystem
  • Desert ecosystem
  • Aquatic ecosystems (ponds, streams, lakes, rivers, oceans, estuaries)

Unit 3: Natural Resources: Renewable and Non-renewable Resources

  • Land Resources and land use change; land degradation, soil erosion and desertification.
  • Deforestation: Causes and impacts due to mining, dam building on environment, forests, biodiversity and tribal populations.
  • Water: use and over exploitation of surface and ground water, floods, droughts, conflicts over water (international and inter-state).
  • Energy resources: Renewable and non-renewable energy sources, use of alternate energy sources, growing energy needs, case studies.

Unit 4: Biodiversity and Conservation

  • Levels of biological diversity: genetic, species and ecosystem diversity; Biogeographic zones of India; Biodiversity patterns and global biodiversity hot sports.
  • India as a mega-biodiversity nation; Endangered and endemic species of India
  • Threats to biodiversity: Habitat loss, poaching of wildlife, man-wildlife conflicts, biological invasions; Conservation of biodiversity: In-situ and Ex-situ conservation of biodiversity.
  • Ecosystem and biodiversity services: Ecological, economic, social, ethical, aesthetic and informational value.

Unit 5: Environmental Pollution

  • Environmental Pollution: types, causes, effects and controls, Air, water, soil and noise pollution
  • Nuclear Hazard and human health risks
  • Solid waste management: Control measures of urban and Industrial waste
  • Pollution case studies

Unit 6: Environmental Policies and Practices

  • Sustainability and sustainable development
  • Climate change, global warming, ozone layer depletion, acid rain and impact of human communities and agriculture
  • Environment Laws: Environment protection act; Air (prevention and control of pollution) Act; Water (Prevention and control of Pollution) Act; Wildlife Protection Act: Forest Conservation Act.
  • Nature reserves, tribal population and rights, and human wildlife conflicts in Indian context.

Unit 7: Human communities and the Environment

  • Human population growth: Impacts on environment, human health and welfare.
  • Resettlement and rehabilitation of project affected persons: case studies
  • Disaster management: flood, earthquake, cyclones and landslides.
  • Environmental Movements: Chipko, Silent Valley, Bishnois of Rajasthan
  • Environmental Ethics: Role of Indian and other religions and cultures in environmental conservation
  • Environmental communication and public awareness, case studies (e.g. CNG vehicles in Delhi).

Unit 8: Field work

  • Visit to an area to document environmental assets: river/forest/flora/fauna etc.
  • Visit to local polluted site – Urban/Rural/Industrial/Agricultural
  • Study of common plants, insects, birds and basic principles of identification.

Study of simple ecosystems – pond, river, Delhi ridge etc.

Organic Chemistry for Chemical Engineering Sciences – B. Singh | Integrated Science

Book : Organic Chemistry for Engineering Sciences

Author : Bhupender Singh

Edition : 1st Year of publication 2013

ISBN : 978-93-5126-559-7 Publisher: Integrated Science

To purchase this book, contact us through contactus page.

Table of Contents

   An Introduction to Organic Reactions  

. Type of organic reactions          

. Energy changes in Reactions    

. Reaction Intermediates             

Carbocations     

Carbanions        

Free Radicals     

Carbenes            

. Reaction Mechanisms

.. Substitution Reactions              

Nucleophilic Substitution reactions         

Electrophilic Substitution reactions         

Free Radical Substitution reactions         

.. Addition Reactions     

Electrophilic Addition reactions 

Nucleophilic Addition reactions

Free radical addition reactions  

.. Elimination Reactions

.. Molecular Rearrangements    

Nucleophilic rearrangements    

Electrophilic rearrangements     

Free radical rearrangement        

. Oxidation and Reduction Reactions      

   Chemistry of  Hydrocarbons    

. Alkanes             

Preparation       

Physical Properties of Alkanes  

Chemical Properties of Alkanes

Petroleum         

Petroleum Origin            

Natural Gas       

Composition of Petroleum         

Petroleum Mining          

Petroleum Refining        

Cracking              

Reforming          

Octane number               

. CycloAlkanes  

Nomenclature  

Classification     

Synthesis of Alicyclic Compounds            

Physical Properties of cycloalkanes         

Chemical Properties      

Baeyer Strain Theory     

MO theory or orbital picture of angle strain        

Stability of Cyclohexane               

Substitution reactions   

Addition reaction            

. Alkenes            

Nomenclature  

Preparation       

Physical Properties         

Chemical Properties      

. Dienes               

Conjugated Dienes        

Preparation       

Chemical Properties      

. Alkynes             

Acidity of Alkynes           

Preparation       

Physical Properties         

Chemical Properties      

. Aromatic Hydrocarbons             

Nomenclature  

Structure            

Aromaticity        

Chemical Reactions and Directive effect               

Effect of substituent on Reactivity          

  Chemistry of  Functional Groups            

Hydrocarbon Halides     

Synthesis            

Physical Properties         

Chemical Properties      

Organometallic Reagents            

Grignard Reagents         

Preparation       

Physical Properties         

Chemical Properties      

Organolithiums

Preparation       

Properties          

Polyalcohols (glycols) or polyhydric alcohols        

Dihydric Alcohols (Diols)               

Properties          

Ethylene Glycol

Preparation       

Physical Properties         

Chemical Properties      

Aldehydes and ketones               

Structure of the Aldehyde and Ketones

Methods of Preparation              

Physical Properties of Aldehyde               

Chemical Properties of Aldehydes          

Carboxylic acids

Preparation       

Physical Properties         

Chemical Properties      

Acyl Chlorides   

Preparation of Acid Chlorides    

Physical Properties of Acid Chlorides      

Chemical Properties of Acid Chlorides   

Acid Anhydrides              

Preparation of Acid Anhydrides

Physical properties         

Chemical properties      

Diazonium Salts

Preparation       

Physical properties         

Chemical properties      

Synthetic use of diazonium salts              

Pyridine              

Structure            

Synthesis            

Properties          

Chemical Reactions        

  Chromatography           

. Introduction   

Theory 

Classification     

. Thin Layer Chromatography (TLC)         

Theory of TLC   

Stationary phases           

Mobile phases 

Experimental: Analysis of a Mixture by Thin Layer Chromatography        

Application and Uses of TLC       

. Column Chromatography          

Experimental Procedure for Column Chromatography   

. Wet Packing    

. Dry Packing     

Sample Loading

Elution 

Development   

Application and Uses of Column Chromatography           

Normal to high pressure chromatography           

NPLC, MPLC and HPLC  

Normal Phase and Reverse Phase Chromatography        

Liquid Chromatography types   

High Performance Liquid Chromatography (HPLC)           

Reverse phase HPLC      

Instrumentation for HPLC           

Solvents              

Pump   

Injector               

Column

Detector             

Applications of HPLC      

Partition Chromatography          

Theoretical plates theory:           

Paper chromatography

Gas Chromatography    

Theory 

Instrumentation              

Injection port   

Detector             

Applications of GC          

Gel Permeation Chromatography (GPC)               

Theory 

Experimental GPC          

Applications of Gel permeation chromatography             

 Ultra Violet Spectroscopy           

Introduction      

The Electromagnetic Spectrum 

Principles of Absorption Spectroscopy  

UV-Visible Absorption Spectra (Electronic energy levels, electronic transitions and selection rules)          

General appearance of UV bands            

Factors affecting absorption      

Effect of Conjugation on wavelength maxima:  

Introduction to Woodward-Fieser Rules               

Conjugated Dienes        

Conjugated Aldehydes and Ketones      

The ultraviolet spectrometer     

 Infra Red Spectroscopy               

Introduction      

Theory 

Stretching Vibrations     

Bending Vibrations         

Fundamental vibrations and overtones

Infrared Vibrations – Active and Forbidden (Selection Rule)        

Interpreting a IR spectra              

Authors Guidelines for Biomedical Science Journal

The Authors need to submit a single file containing all the details as described below. The supplementary data files should be submitted as a separate file. Authors are advised to prepare their manuscript according to journal article template provided below.

Cover letter

Authors should supply a cover letter indicating rational of their work. Cover letter should also have details of at least three reviewers (with email). Cover letter should be provided on the first step of submission in “Comments for Editor’ box.

Graphical Abstract

Authors need to submit a graphical abstract highlighting the contents of manuscript. Graphical abstract could be submitted as supplementary file or on the last page of manuscript. The preferred image size of graphical abstract is 700px x 250px

Manuscript

Manuscript should include Title, Author (s), Affiliation (complete name of institutions), Abstract, 5 Keywords, (other sections like Introduction, Results and discussion, conclusion, experimental procedures in the main body text of manuscript could be used for full paper article), acknowledgment and references in the listed order. Short communications need not to be arranged in different sections. References should be formatted as shown for articles,1 theses,2 books,3,4 and patents,5

  1. R. Ping, M. Laura, P.S. Mario. Title of the journal article should be included here. Int. Lett.Org. Chem. 1996, 61, 4439–4449.
  2. B.K. Sharma. Ph.D. Dissertation, Thesis Title, Cornell University, 1995.
  3. R. Hussain, D. Shinkoi. Title of book like Synthesis and application of ionic liquid, John Wiley & Sons: New York, 2010.
  4. R.S. Buchanod, D.K. Reddy. In Selective Organic Transformations; T.R. Thyagarajan, Ed.; Integrated science: New York, 2002; Vol. 2, pp 1–95.
  5. G.L. Loyale, U.S. Patent 5 934 456, 1998; Chem. Abstr. 1998, 65, 2870.

Citation Manager style files: Authors are highly encouraged to use the citation manager programs for citing and formatting the references. Authors may use free Mendelay, Zotero, Paper 2 or Endnote program. If you are using any of these citation manager program for Bibliography (References and Notes), then you can download citation style file for journal (common for ISP journals):

Mendelay, Zotero, Paper 2 style file: ISP Journals CSL style file

Endnote style file: ISP Journals Endnote style file Or ChemBiolLett style file (click and download from google drive … and copy the file to Endnote style folder or open in EndNote).

click to download and then open in respective program (the user can see the respective program user guide on how to use the style file).

On acceptance of manuscript, authors must need to supply their manuscript in Article template (if they have not already submitted in template).

Submission

Authors need to submit all manuscripts through journal website. Register by following link ‘Register’ above (make sure to mark checked the options Author and reviewer while registering for journal). On login, you will find ‘new submission’ link in your panel page.

Templates

On acceptance of manuscript, Authors are required to submit revised manuscript in journal articles template (If authors wish, they are free to submit their manuscript in journal article template while submitting first time).

Biomedical Sciences Word2007-2010_template (click and download from google drive..)

download the template (as per the MS Word version that you have on your computer), double click the file to open and then prepare your article and save it with your own name.

Login and submit the manuscript online (submission by email are not accepted). Only online submissions are accepted now.

On acceptance of manuscript, Authors need to send ‘Copyright Transfer form’ (signed by all authors).

Source:: http://pubs.thesciencein.org/authors-guidelines-for-biomedical-science-journal/

      

urn:nbn:sciencein.jmns.2019v6.84

Conductive polymer nanocomposite enzyme immobilized biosensor for pesticide detection

  • Priyanka D Virutkar

    Rashtrasant Tukadoji Maharaj Nagpur University

  • Ashish P Mahajan

    Rashtrasant Tukadoji Maharaj Nagpur University

  • Bhavna H Meshram

    Rashtrasant Tukadoji Maharaj Nagpur University

  • Subhash B Kondawar

    Rashtrasant Tukadoji Maharaj Nagpur University

Keywords:

Carbon nanotubes, Acetylcholinesterase,
Pesticides, Biosensors

Abstract

Conductive carbon nanotubes based polyaniline/polypyrrole
polymer nanocomposite (CNT-PANI-PPy) film was electrochemically
synthesized on graphite electrode using cyclic voltammetry. CNT-PANI-PPy
film formed a biocompatible environment to entrap enzyme molecule and
used as biosensor for pesticide detection. This study shows that enzyme
based conductive polymer nanocomposite film itself acts as a mediator.
Carbon nanotubes promote electron transfer reactions in presence of
Acetythiocholine chloride (ATCl) as a substrate at a lower potential and
catalyzed the electrochemical oxidation of enzymatically formed
thiocholine. Surface morphology was studied by scanning electron
microscopy which shows a porous structure of the modified film
beneficial for enzyme immobilization. Electrochemical behavior of the
fabricated electrodes evaluated through cyclic voltammetry and
electrochemical impedance spectroscopy. The detection of pesticide
(acephate) was performed by chronoamperometry and the limit of detection
(LOD) of acephate was found to be 0.007 ppm concentration which is
quite low.

Full text at: http://pubs.thesciencein.org/journal/index.php/jmns/article/view/84

Source:: http://pubs.thesciencein.org/urnnbnsciencein-jmns-2019v6-84/