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Prof. Santanu Bhattacharya | Materials NanoScience Editorial Advisory Board Member

Professor S. Bhattacharya did Ph.D. from Rutgers University, New Brunswick, NJ, USA (Advisor: Prof. Robert. A. Moss) in 1988. From 1988 to 1991 he worked as Postdoctoral Research Associate at the Massachusetts Institute of Technology, Cambridge, MA, USA (Prof. Har Gobind Khorana, Nobel Laureate) and in 1991 he joined as Assistant Professor in Organic Chemistry division, Indian Institute of Science, Bangalore, India where he was promoted as Professor in 2001. He served as Chairman of department of Organic Chemistry, Indian Institute of Science from 2012 to 2015 and since April 22, 2015 he is Director and Senior Professor, Director’s Research Unit, Indian Association for the Cultivation of Science (IACS), Kolkata. India.

He has received numerous excellence awards such as
Ranbaxy Research Award, Pharmaceutical Sci., Ranbaxy Science Foundation 2013
Elected Fellow of the World Academy of Sciences 2012
TWAS Prize, The World Academy of Sciences, Trieste, Italy 2010
J. C. Bose National Fellowship, Department of Science & Technlogy 2008
Elected Fellow of Indian National Science Academy 2007
G.D. Birla Prize for Scientific Research, K.K. Birla Foundation 2007
Shanti Swarup Bhatnagar prize for the Chemical Sciences, CSIR 2003
National Bioscience Career Development Award, Department of Biotechnlogy 2002
Elected Fellow of Indian Academy of Sciences 2000
Swarnajayanti Fellowship, Department of Science & Technlogy 1998

He is associated with ‘Journal of Materials NanoScience‘ as Editorial Advisory Board Member since 2014. The journal link is http://www.pubs.iscience.in/journal/index.php/jmns

Synthesis and Evaluation of [DUPA-6-Ahx-Lys (DOTA)-6-Ahx-RM2], a Novel, Bivalent Targeting Ligand for GRPr/PSMA Biomarkers of Prostate Cancer

In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, or Lu). These new agents, when radiolabeled with Ga-68, In-111, or Lu-177 hold theranostic potential for patients presenting with prostate cancer disease.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/718

      

Synthesis and evaluation of a novel 68Ga-NODAGA-Erlotinib analogue towards PET imaging of Epidermal Growth Factor Receptor over-expressing cancers

In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also exhibited high in vitro stability. The log P value of 68Ga-NODAGA-Erlotinib was lower than that of 68Ga-NOTA-Erlotinib, a 68Ga based Erlotinib conjugate previously reported by our group. In the in vitro cell binding studies carried out in EGFR-positive A431 cells, 68Ga-NODAGA-erlotinib exhibited an uptake (7.8±1.3 %) lower than that of 68Ga-NOTA-Erlotinib (9.8±0.4%) showing that an increase in hydrophilicity possibly effected a decrease in cell permeability. The higher hydrophilicity of 68Ga-NODAGA-Erlotinib also led to significantly lower accumulation of 68Ga-NODAGA-Erlotinib in non-target organs in the biodistribution studies in Swiss mice. The overall properties of the 68Ga-NODAGA-Erlotinib conjugate are promising and reflect the role of hydrophilicity in reducing the non-specific uptake of the final radiotracer towards improving signal/noise ratio for further imaging studies.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/727

      

Dr Brijesh Rathi

Dr. Brijesh Rathi,
Department of Chemistry,
Hansraj College,
University of Delhi,
Delhi-110007. India

webpage: http://hansrajcollege.ac.in/faculty-info.php?id=28

Research Interests: Medicinal Chemistry, Maleria, Drug development, synthetic organic chemistry, peptide chemistry, peptide drugs, nanomedicine.

Dr. Brijesh Rathi is a faculty of Chemistry in Hansraj College, University of Delhi and associated with Chemical Biology Letters and Applied NanoMedicine as Editorial Board Member.

Prof. Carmela Saturnino

Carmela Saturnino
Prof. in Medicinal Chemistry
Department of Science
University of Basilicata
viale dell’Ateneo Lucano
Potenza
ITALY

Research Interest: Medicinal Chemistry

Prof. Saturnino is Professor of Medicinal Chemistry in University of Basilicata, Italy and associated with Chemical Biology Letters ( http://pubs.iscience.in/journal/index.php/cbl/pages/view/editorialboard ) as Editorial Advisory Board Member.

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Optimization of recovery of antioxidants from the coconut shell using Response Surface Methodology

Coconut shell is an important byproduct of Cocos nucifera L. which is largely being wasted. The present study is focused on optimizing the extraction process of phenolic compounds and also to evaluate its physico-chemical and antioxidant properties. After studying the effect of different solvents and different extraction conditions, methanol was found to be the most effective solvent and extraction at 90oC was suitable to give high phenolic yield (4045 mg GAE/100 g). For further precision of the ideal conditions, response surface methodology was carried out to optimize the solvent concentration, temperature and extraction time. The results revealed that methanol at 72%, extraction time 167 min and temperature 68oC yielded maximal level of polyphenols from coconut shell. Both extraction temperature and solvent concentration were found to have significant effect on the phenolic yield. Suitable conditions could be applied to recover the antioxidant phenolic compounds from the coconut shell, an agricultural byproduct available at huge quantity in India. The physico-chemical and antioxidant properties of methanolic extract of coconut shell were noticed to be suitable for its application in food and pharmaceutical industries.

Source:: http://www.pubs.iscience.in/journal/index.php/jbts/article/view/681

      

Current trends in nanomedicine and nanobiotechnology research

Applications of Nanoparticles and nanopharmulations in drug development and drug delivery have been an extensive field of research to find out the alternative better therapeutics. The past research in nanomedicine and nanobiotechnology mostly emphasized on improving the profile of existing drugs, however, a recent pattern has seen in variation of field and aspects studied using nanomedicine. The current nanomedicine research has oriented in developing new drugs based on the interaction of nanoparticles on targets like cancer therapeutics, development of new biosensors, bioimaging (cellular and in vivo), new vistas of anti-viral drugs, besides the most researched field of nano delivery of drugs for cancer, diabetes, anti-bacterial, and other ailments. An overview of current research trends is presented based on the literature published at different platforms in recent time.

Source:: http://www.pubs.iscience.in/journal/index.php/appnanomed/article/view/747

      

Synthesis of novel 2-(3-aryl/alkylamino propoxy)-12-aryl xanthene derivatives as antifungal and antibacterial agents

By admin By Bhaskara Nand, Kalawati Meena, Shruti Gupta, J.M. Khurana, Amita Malik, Chetan Sharma, Harsh Panwar A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H– benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. […]

Source:: http://pubs.iscience.in/synthesis-of-novel-2-3-arylalkylamino-propoxy-12-aryl-xanthene-derivatives-as-antifungal-and-antibacterial-agents/

      

Synthesis of novel 2-(3-aryl/alkylamino propoxy)-12-aryl xanthene derivatives as antifungal and antibacterial agents

By Bhaskara Nand, Kalawati Meena, Shruti Gupta, J.M. Khurana, Amita Malik, Chetan Sharma, Harsh Panwar A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H– benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. Structures have been confirmed by spectroscopic analysis. All the newly synthesized 2-(3- aryl/alkylaminopropoxy)-12-aryl xanthene derivatives were screened for their antimicrobial activity against four microbial strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The selected synthesized compounds showed moderate antimicrobial activity.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/695