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Optoelectronic properties of single and array of 1-D III-nitride nanostructures: An approach to light-driven device and energy resourcing

One dimensional (1-D) group III-nitride nanostructures are important components of optoelectronic devices owing to its unique feature of unidirectional carrier flow, and efficient electrical connectivity. The group III-nitride materials are attractive for the application as low power white and blue–green light sources provide a green and extended operational life. We discuss the luminescence phenomena observed in single or arrayed 1-D III-nitride nanostructures including quantum wells. The role of these 1-D nanostructures is critically reviewed in the field of ‘green’ energy generation, namely hydrogen source in fuel cells, the photoelectrochemical workhorse in renewable energy resourcing, and in solar cells.

Source:: http://www.pubs.iscience.in/journal/index.php/jmns/article/view/759

      

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Chemical extraction and biomedical importance of secondary organic metabolites from plants – A review

Medicinal plants are the important source of potentially useful chemotherapeutic agents which have made enormous contributions to human health and well-being. The bacteria, fungi, virus, etc have developed resistance against available drugs. The secondary metabolites of the variety of plants can serve as major source for the development of new drugs for the treatment of different diseases and infections. Depending upon the bioactive constituents present in the plant sample, these metabolites are extracted by different methods including most recent soxhlet, microwave, ultrasound, supercritical fluid, etc extractions. The different groups of secondary metabolites with their structural variations, chemical extraction methods and their potent biomedical applications have been discussed in this review.

Source:: http://www.pubs.iscience.in/journal/index.php/jbts/article/view/772

      

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Assessment of Anti-diabetic and Anti-oxidant activity of Murraya Koenigii extracts using in-vitro assays

Murraya koenigii, commonly known as curry leaves, is a regular ingredient used in Indian cuisines. Not only it is beneficial for health but also it is speculated to have various medicinal properties. Although a large number of phytochemicals have been identified and tested for various properties but no compound have been extended for drug design purpose. Present work conducted on Murraya koenigii illustrates its anti-diabetic and anti-oxidant activities using various biochemical tests. From various evaluated leaf extracts of M.koenigii, DCM and Ethanol extracts were the one which showed best activity for anti-oxidant and anti-diabetic assays.

Source:: http://www.pubs.iscience.in/journal/index.php/jbts/article/view/765

      

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Design, synthesis and Structure-Activity Relationship of novel Phenolic based Pyrimidine hybrids from Cashew Nut Shell Liquid (CNSL) components as potential antitumor agents

Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (15a-15t) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut shell liquid (CNSL). All the newly synthesized compounds were screened for their in vitro antitumor activity. Baylis-Hillman compounds 5b and 5h showed promising anticancer activity against MCF-7. Among pyrimidine derivatives, compounds 15i, 15j and 15l showed promising activity against HEP-G2, whereas compounds 15j, 15k, 15l and 15m showed promising activity against MCF-7. In addition, compound 15m showed significant activity against K562 when compared with the standard. The structure-activity relationship (SAR) analysis suggests that the length of the carbon chain of phenyl ring played an important role in the potency of activity.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/753

      

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Radiopharmaceuticals for diagnosis of Primary Hyperparathyroidism

Hyperparathyroidism (HPTH) is a condition in which the level of parathyroid hormone in blood is raised. Gold standard for the diagnosis of HPTH is a measurement of serum parathyroid hormone levels, accompanied by testing serum calcium levels, to differentiate between primary and secondary HPTH. The first line of treatment with primary HPTH is surgery to remove the adenoma or the tumor, whenever possible. It is in these cases that the imaging plays an important role for localization of tumor before surgery.Imaging can be anatomical that is ultrasound, CT and MRI or functional that is using nuclear medicine modalities (SPECT, SPECT/CT, PET/CT). This article reviews the nuclear medicine modalities, various radiopharmaceuticals and imaging techniques for parathyroid imaging.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/726

      

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Radiolabelled nanoparticles in cancer treatment: current status and developments

The current concepts of cancer therapy are moving towards personalized treatment regimen aiming to reduce toxicity and improve efficacy of therapeutic agents. With the development of molecular imaging and targeted therapies personalized care has received a shot in the arm. However, these developments are not without challenges. Drug delivery, metabolism, toxicity etc. challenge the effective utilization of such agents. Nanoparticles offer to overcome these hurdles with their unique physico-chemical properties which can be labeled with radionuclides and conjugated with ligands to achieve high specific activity in the intended areas. In this article, we discuss the present status of radiolabeled nanoparticles, the areas where they are being used and challenges that lie ahead. We intend to provide a basic outlook on the utilization of radiolabeled nanoparticles in cancer diagnosis and therapy.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/728

      

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