urn:nbn:sciencein.cbl.2020v7.101

In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins

Published in: Chemical Biology Letters

Authors

• Vaishali Chandel Amity University
• Mitul Srivastava Translational Health Science and Technology Institute
• Ashutosh Srivastava Amity University
• Shailendra Asthana Translational Health Science and Technology Institute
• Dhruv Kumar Amity University Uttar Pradesh, Noida

Keywords: Phytochemicals, Oncoproteins, Molecular docking, Molecular dynamics, simulations

Abstract

Cancer is the leading cause of mortality worldwide. Conventional chemotherapeutic agents pose a drawback as they are nonspecific. There is an urgent need to identify and design novel targets specific to the tumor. Almost 90,000 species of plants are used as a source of medicines to treat the majority of the disease including cancer. The objective of this study was to understand the interactions between the active phytochemicals selected on the basis of literature review and target oncoproteins in order to find out the biomolecules having strongest bonding actions. Molecular Docking of c-MYC, EGFR and ERBB2 with the selected Phytochemicals showed highest binding energy -7.8 Kcal/mol of EGCG with c-MYC, -8.7 Kcal/mol of Curcumin with EGFR, and -9.4 Kcal/mol of Quercetin with ERBB2. Moreover, molecular dynamics simulation data showed all three phytochemicals exhibits strong stability on their respective targets. Our studies reveal that these three phytochemicals could be promising candidates in designing and optimizing therapeutic strategies against cancer.

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Cite as:

Chandel, V., Srivastava, M., Srivastava, A., Asthana, S., & Kumar, D. (2020). In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins. Chemical Biology Letters, 7(1), 47-54.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/101

Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review

• Parul Pant

  University of Delhi

• Dr. Chetna Gupta

  University of Delhi

• Sagar Kumar

  Indian Institute of Science

• Apoorva Grewal

  University of Delhi

• Shivani Garg

  University of Delhi

• Aishwarya Rai

  University of Delhi

Keywords:

Silica, Nanoparticles,
trumeric, drug delivery, cancer,
diabetes, nanomedicine, biomedical science

Abstract

Silica nanoparticles offer a promising platform for the delivery of drugs, in particular for the drugs which lack water solubility, target capability and have non-specific distribution, systematic toxicity and low therapeutic index. In this review, we focus on the synthesis and therapeutic (particularly, anti-cancer) applications of Curcumin loaded Silica Nanoparticles. Various surface modifications of silica nanoparticles have been discussed that are used to enhance their therapeutic applications. The characterization techniques and study of their biocompatibility have also been presented.

Cite as: Pant, P., Gupta , C., Kumar, S., Grewal, A., Garg, S., & Rai, A. (2020). Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review. Journal of Materials NanoScience, 7(1), 1-18.

Full text at http://thesciencein.org/journal/index.php/jmns/article/view/99 and

Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics

urn:nbn:sciencein.cbl.2020v7.103

A review on Corona Virus Disease COVID-19, epidemiology, prevention, and anticipated therapeutic advances

Published in Chemical Biology Letters

• Bhupender S. Chhikara University of Delhi
• Brijesh Rathi University of Delhi
• Jyoti Singh M.D. University
• Poonam University of Delhi

Keywords: New Virus, SARS-Cov-2, Corona Virus, Pharmaceuticals, Medicinal Chemistry, Diagnosis, Chemical Drugs, Epidemiology, Cell Mechanism, Anti-viral drugs, Antibody Therapy, Pharmacology

Abstract

The recent outbreak of Corona virus SARS-CoV-2 disease COVID-19 in the China and subsequent intermittent spread of infection to other countries has alarmed the medical and scientific community mainly because of lethal nature of this infection. Being a new virus in the category, the immediate emergency therapy is not available for the treatment of this disease, leading to widespread fear of infection and has created social issues for infected peoples. Herein, the epidemiology of COVID-19 infection, transmission characteristics of SARS-CoV-2 virus spread, effectiveness of preventive measures, coronavirus family, structural characteristics of virus, current literature advances for the diagnostics development (RT-PCR, CT-Scan, Elisa) and possible drug development based virus life cycle (Entry inhibitors, replication inhibitors, nucleoside, nucleotide, protease inhibitors, heterocyclic drugs, including biological therapeutics (monoclonal antibodies therapy, vaccine development) and herbal formulations have been reviewed. The chemical drug molecules with prospective application in the treatment of COVID-19 have been included in the discussion.

Cite as: Chhikara, B. S., Rathi, B., Singh, J., & Poonam (2020). Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics: A review on Corona Virus Disease COVID-19, epidemiology, prevention, and anticipated therapeutic advances. Chemical Biology Letters, 7(1), 63-72.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/103

This is open access article published as part of priority information sharing for emergency infection COVID-19 (CBL journal confirmed its association for the priority availability of articles related with COVID-19 infection with Open Access (The Wellcome Trust, U.K. signatories).

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Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases

URN:NBN:sciencein.cbl.2020.v7.102

Published in Chemical Biology Letters

Anti cancer mechanism of Ziziphus jujube Ber extract

• Radhakrishna G Pillai

  University of Calicut

Keywords:

cancer, proapoptotic genes,
phytochemical, diet, HEK293,
phytomedicine, anti-cancer nutrients, herbal
drugs

Abstract

Severe side effects as well as the cost of chemotherapy necessitate the need for alternative therapies. Use of plant derived drugs is on the increase for the treatment of various diseases including cancer. This study was designed to explore the effects of the aqueous extract of the ripe fruits of Ziziphus jujube on MCF-7, HCT116 and HEK 293 cell lines to examine the possibility of it being developed as a therapeutic aid in cancer treatment. Cells were exposed to different doses (0-2mg/ml) of the aqueous extract for different time durations ranging from 24h to 72hr. Cell viability and the change in expression of various apoptosis related genes such as Bcl2, Bax, caspase-3 and caspase-9 were studied. Rate of proliferation of the cancer cells (MCF-7 and HCT116) decreased on exposure to the extract in a time and concentration dependent manner. Expression levels of all the genes studied, except Bcl2, showed an increase. Bcl2 expression was inversely proportional to time and concentration of the extract. Levels of activated caspases 3 and 9 were also increased. This report points to the possibility of developing the extract of Ziziphus jujube as a drug for the treatment of cancer.

How to Cite Pillai, R. G. (2020). Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases: Anti cancer mechanism of Ziziphus jujube Ber extract. Chemical Biology Letters, 7(1), 41-46.

Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/102 and/or http://pubs.iscience.in/journal/index.php/cbl/article/view/948

Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)

urn:nbn:sciencein.cbl.2020.v7.96

Published in: Chemical Biology Letters

• Pooja Mittal

  University of Delhi

• Sujata Singh

  University of Delhi

• Archana Singh

  University of Delhi

• Indrakant K. Singh

  University of Delhi

Keywords: Drug delivery, Nanomedicine, Nanobiotechnology, Liposome, Nanoparticles, Hydrogels, Aptamer

Abstract

Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.

Cite as: Mittal, P.; Singh, S.; Singh, A.; Singh, I. K. Current Advances in Drug Delivery Systems for Treatment of Triple Negative Breast Cancer (TNBC). Chem Biol Lett 2020, 7(1), 1-12.

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http://www.pubs.iscience.in/journal/index.php/cbl/article/view/941

http://thesciencein.org/journal/index.php/cbl/article/view/96