Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor

One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol extract of Bornetella oligospora, an abundant green alga in eastern Indonesia. The result showed that ethanol and ethyl acetate extract of Bornetella oligospora contained phytochemical components such as flavonoid, glycoside, triterpenoid, and steroid. The thin layer chromatography test showed ethanol extract have five spots with Rf 0.545, 0.527, 0.5, 0.473, and 0.154, while the ethyl acetate extract has two spots with Rf 0.58 and 0.64. The alpha-glucosidase inhibition assay showed IC50 values of the ethanol extract was 11.702 ug/mL and ethyl acetate extract was 95.384 ug/mL. In conclusion, Bornetella oligospora extract has the potential as an antidiabetic agent.

Published in Chemical Biology Letters

Siswanto, M. A., Paramita, R. I., Fadilah, F., & Poerwaningsih, E. H. (2021). Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor. Chemical Biology Letters, 8(1), 40–44.

Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air

Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and glutathione reductase, were estimated biochemically and the expression of Nrf2 and glutathione peroxidase genes were estimated by reverse transcriptase PCR. Plasma ALT, AST, ALP, MDA and the activity of antioxidant enzymes; SOD, GRd, catalase were found increased significantly in ambient air exposed rats. Ambient air exposure decreased the levels of glutathione, non protein thiols and GPx expression whereas total thiols and expression of Nrf2 increased. However the concurrent administration of astaxanthin was found to reverse these changes in a dose dependent manner. The results of this study revealed the ability of astaxanthin to alleviate liver toxicity and oxidative stress induced by ambient air exposure and points to the possibility of developing astaxanthin as a dietary supplement that reduce the ill effect of toxic chemicals from ambient air.

Published in: Chemical Biology Letters

Johnson, J. P., Renganthan, S., Menon, A., & Pillai, R. G. (2021). Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air. Chemical Biology Letters, 8(1), 1–9.

Biosensors for Detecting Imbalances of Life Systems: Role of Materials and Methods in Improved Outcome

Any deviation or imbalance from homeostatic state of steady internal physical and chemical conditions in living systems, generally falls under category of disease. Chances of bringing them back to normalcy or closer to healthier state with therapeutic interventions are found to be more successful when they are applied at very early stage. Biosensing has emerged as a process to achieve early detection of deviations in such homeostatic states via evaluation of physiological, chemical, or biomolecular parameters in the subjects. The two main components on which efficiency of biosensors rely are materials used as platform technology and methods of detection used for the task. In this issue we will be assembling recent advancements in the field of Biosensors in terms of used materials and methods in achieving high sensitivity, specificity and predictability in form of original research.

Topic Editor

Santosh Misra, Ph.D.
Dept of Biological Sciences & Bioengineering,
Indian Institute of Technology,
IIT Kanpur, U.P., IN

Schedule – The dates

Abstract Submission: September 30, 2021
Article Submission: January 31, 2022 (Processing – ‘as we go’ model)
Issue completion: May 30, 2022

Field – Research area
NanoMedicine & Biomaterials
NanoChemistry and Chemistry Materials
NanoScience Nanotechnology
Polymer and Functional Materials
Materials Science

Participating Journal

Journal of Materials NanoScience – Nanomedicine section


This special issue is under the Lead 20 program where leading scientists/academicians in the above field with well established lab, good publication record (an online link in form is required) and are under the age of 40 will be eligible to participate in this compilation. The editor will choose the best leading scholars from all the submitted entries (selection will be at abstract submission level as well as at full article level through peer review.

Authors / Abstracts

This is new recent Topic announced, the list of authors/abstracts will be updated here. This is an open invitations for interested researchers to submit the abstract for this topic. Submit the abstract with detail below:

The abstract details can also be forwarded directly to topic editor or editorial office at pubs @ thesciencein (dot) org

Immunoendocrine regulation of energy homeostasis and male reproduction

Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.

This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.

Potential topics include but are not limited to the following:

  • Energy homeostasis  and male reproduction
  • Immunoendocrine regulation of male reproductive functions
  • Adipokines and energy metabolism in male fertility
  • Obesity and male infertility: energy imbalance to inflammation
  • Endocrine regulation of epigenetics of reproductive tract inflammation
  • Altered energy metabolism and immune regulation in aged men
Submission Deadline 30th June 2021
Publication Date 1st Sept 2021

Guest Editors:

Pallav Sengupta, PhD
Department of Physiology
Faculty of Medicine & Biomedical Sciences
MAHSA University
Sulagna Dutta, PhD
Department of Physiology
Faculty of Dentistry
MAHSA University


Article (Research articles and Review Articles) should be submitted online on the journal site as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

There is no publication charges for publishing in special issue or in Chemical Biology Letters.

Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity


Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

Published in: Chemical Biology Letters

  • Ashish Bhatt

    Mewar University

  • Krishna Srivastava

    Shri Ramswaroop Memorial University

  • Ravi Kant

    Shri Ramswaroop Memorial University

  • Deepa Lakhmani

    Shri Ramswaroop Memorial University


1,1-biphenyl-4,4-diamine, Antibacterial activity,
anti-microbial activity


Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.

Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.

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