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Category: Medicinal Chemistry

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  • Infections and Immunity

    Amidst the present pandemic, there has been a lot of talk about the role of immunity in handling the outbreak. A sudden surge of information on various aspects of immunity in infections has ignited curiosity and awareness among the common people about the role and scope of immunity.

    The University of Delhi, Daulat Ram College is going to host a 3-day International Conference on “Infections and Immunity” with aim towards a global collaboration between scientists, research scholars and students working on various aspects of immunology from different research organizations, medical institutions, NGOs, and reputed Universities, to share their ideas and discuss the solutions. The selected full length articles from speakers, participants and other scholars will be published in special thematic issue.

    This special issue is meant to cover the various aspects of emerging infectious diseases, problems, and solutions to deal with possible infections of future. It will bring together the knowledge of the paradigms of infectious diseases and the recent researches related to this area including the role of both innate and acquired immunity. It also aims to explore the role of vaccine and the challenges in vaccine development against the infectious agents. The special issue will include articles on recent therapeutic and diagnostic tools in tackling infections, developments and challenges in vaccine and immunity with emphasis on most recent research findings.

    Themes of special issue and associated Session of Conference are:

    • Genomic surveillance of infective agents
    • Efficacy of immune system
    • Possible role of Artificial intelligence in COVID-19
    • Infections and vaccines
    • Vaccine design
    • Covid infections, modalities and its management

    Guest editors

    Dr. Indrakant K. Singh,
    Associate Professor, Zoology 
    Deshbandhu College, University of Delhi

    Dr. Rajesh Pandey
    Associate Professor, (AcSIR)
    Principal Scientist, (CSIR-IGIB), Delhi

    The Dates / Schedule

    Article Submission date- November 15, 2021
    Issue completion date- December 31, 2021

    Participating Journal

    Chemical Biology Letters

    Submission

    Interested scholars should submit their article (prepared according to author guidelines in the journal article template) on the journal site
    https://pubs.thesciencein.org/journal/index.php/cbl (In cover letters to editor mention that article is for consideration in special issue). Authors can also submit their article manuscript directly to guest editors for preliminary editorial processing.

  • Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor

    One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol extract of Bornetella oligospora, an abundant green alga in eastern Indonesia. The result showed that ethanol and ethyl acetate extract of Bornetella oligospora contained phytochemical components such as flavonoid, glycoside, triterpenoid, and steroid. The thin layer chromatography test showed ethanol extract have five spots with Rf 0.545, 0.527, 0.5, 0.473, and 0.154, while the ethyl acetate extract has two spots with Rf 0.58 and 0.64. The alpha-glucosidase inhibition assay showed IC50 values of the ethanol extract was 11.702 ug/mL and ethyl acetate extract was 95.384 ug/mL. In conclusion, Bornetella oligospora extract has the potential as an antidiabetic agent.

    Published in Chemical Biology Letters

    Siswanto, M. A., Paramita, R. I., Fadilah, F., & Poerwaningsih, E. H. (2021). Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor. Chemical Biology Letters, 8(1), 40–44. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/120

  • Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air

    Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and glutathione reductase, were estimated biochemically and the expression of Nrf2 and glutathione peroxidase genes were estimated by reverse transcriptase PCR. Plasma ALT, AST, ALP, MDA and the activity of antioxidant enzymes; SOD, GRd, catalase were found increased significantly in ambient air exposed rats. Ambient air exposure decreased the levels of glutathione, non protein thiols and GPx expression whereas total thiols and expression of Nrf2 increased. However the concurrent administration of astaxanthin was found to reverse these changes in a dose dependent manner. The results of this study revealed the ability of astaxanthin to alleviate liver toxicity and oxidative stress induced by ambient air exposure and points to the possibility of developing astaxanthin as a dietary supplement that reduce the ill effect of toxic chemicals from ambient air.

    Published in: Chemical Biology Letters

    Johnson, J. P., Renganthan, S., Menon, A., & Pillai, R. G. (2021). Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air. Chemical Biology Letters, 8(1), 1–9. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/158

  • Biosensors for Detecting Imbalances of Life Systems: Role of Materials and Methods in Improved Outcome

    Biosensors for Detecting Imbalances of Life Systems: Role of Materials and Methods in Improved Outcome

    Any deviation or imbalance from homeostatic state of steady internal physical and chemical conditions in living systems, generally falls under category of disease. Chances of bringing them back to normalcy or closer to healthier state with therapeutic interventions are found to be more successful when they are applied at very early stage. Biosensing has emerged as a process to achieve early detection of deviations in such homeostatic states via evaluation of physiological, chemical, or biomolecular parameters in the subjects. The two main components on which efficiency of biosensors rely are materials used as platform technology and methods of detection used for the task. In this issue we will be assembling recent advancements in the field of Biosensors in terms of used materials and methods in achieving high sensitivity, specificity and predictability in form of original research.

    Topic Editor

    Santosh Misra, Ph.D.
    Dept of Biological Sciences & Bioengineering,
    Indian Institute of Technology,
    IIT Kanpur, U.P., IN

    Schedule – The dates

    Abstract Submission: September 30, 2021
    Article Submission: January 31, 2022 (Processing – ‘as we go’ model)
    Issue completion: May 30, 2022

     
    Field – Research area
    Biosensors
    NanoMedicine & Biomaterials
    NanoChemistry and Chemistry Materials
    NanoScience Nanotechnology
    Polymer and Functional Materials
    Materials Science

    Participating Journal

    Journal of Materials NanoScience – Nanomedicine section

    Program

    This special issue is under the Lead 20 program where leading scientists/academicians in the above field with well established lab, good publication record (an online link in form is required) and are under the age of 40 will be eligible to participate in this compilation. The editor will choose the best leading scholars from all the submitted entries (selection will be at abstract submission level as well as at full article level through peer review.

    Authors / Abstracts

    This is new recent Topic announced, the list of authors/abstracts will be updated here. This is an open invitations for interested researchers to submit the abstract for this topic. Submit the abstract with detail below:

    The abstract details can also be forwarded directly to topic editor or editorial office at pubs @ thesciencein (dot) org

  • Immunoendocrine regulation of energy homeostasis and male reproduction

    Immunoendocrine regulation of energy homeostasis and male reproduction

    Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.

    This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.

    Potential topics include but are not limited to the following:

    • Energy homeostasis  and male reproduction
    • Immunoendocrine regulation of male reproductive functions
    • Adipokines and energy metabolism in male fertility
    • Obesity and male infertility: energy imbalance to inflammation
    • Endocrine regulation of epigenetics of reproductive tract inflammation
    • Altered energy metabolism and immune regulation in aged men
    Submission Deadline 30th June 2021
    Publication Date 1st Sept 2021

    Guest Editors:

    Pallav Sengupta, PhD
    Department of Physiology
    Faculty of Medicine & Biomedical Sciences
    MAHSA University
    [pallav@mahsa.edu.my; pallav_cu@yahoo.com]
    Sulagna Dutta, PhD
    Department of Physiology
    Faculty of Dentistry
    MAHSA University
    [duttasulagna@mahsa.edu.my; sulagna_dutta11@yahoo.com]

    Submission

    Article (Research articles and Review Articles) should be submitted online on the journal site http://www.thesciencein.org/journal/index.php/cbl as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

    There is no publication charges for publishing in special issue or in Chemical Biology Letters.

  • Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

    urn:nbn:sciencein.cbl.2019v6.107

    Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

    Published in: Chemical Biology Letters

    • Ashish Bhatt

      Mewar University

    • Krishna Srivastava

      Shri Ramswaroop Memorial University

    • Ravi Kant

      Shri Ramswaroop Memorial University

    • Deepa Lakhmani

      Shri Ramswaroop Memorial University

    Keywords:

    4-methyl-1H-isochromen-1-one,
    1,1-biphenyl-4,4-diamine, Antibacterial activity,
    anti-microbial activity

    Abstract

    Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.

    Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.

    Retrieved full text from http://pubs.thesciencein.org/journal/index.php/cbl/article/view/107