Monthly Archives: February 2018

Design, synthesis and Structure-Activity Relationship of novel Phenolic based Pyrimidine hybrids from Cashew Nut Shell Liquid (CNSL) components as potential antitumor agents

Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (15a-15t) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut shell liquid (CNSL). All the newly synthesized compounds were screened for their in vitro antitumor activity. Baylis-Hillman compounds 5b and 5h showed promising anticancer activity against MCF-7. Among pyrimidine derivatives, compounds 15i, 15j and 15l showed promising activity against HEP-G2, whereas compounds 15j, 15k, 15l and 15m showed promising activity against MCF-7. In addition, compound 15m showed significant activity against K562 when compared with the standard. The structure-activity relationship (SAR) analysis suggests that the length of the carbon chain of phenyl ring played an important role in the potency of activity.




Professor Samir Kumar Pal | Materials NanoScience Editorial Advisory Board Member

Professor Samir Kumar Pal,
Department of Chemical, Biological & Macromolecular Sciences,
S.N.Bose National Centre for Basic Sciences,
JD Block, Sector III, Salt Lake,
Kolkata (Calcutta), India

Expertise: Ultra-fast Spectroscopy in Bio molecules and Materials, Biomimetics, DSSC, Nanomedicines, Nano-catalysis, Development of Instruments for biomedical and environmental use.

Recent Publications:

> P. Kar, T. K. Maji, P. K. Sarkar, P. Lemmens and S. K. Pal. Development of a Photo-Catalytic Converter for Potential Use in the Detoxification of Cr(VI) Metal in Water from Natural Resources”, J. Mat. Chem. A (2018)
> P. K. Sarkar, A. Halder, A. Adhikari, N. Polley, S. Darbar, P. Lemmens and S. K. Pal
“DNA-based Fiber Optic Sensor for Direct In-vivo Measurement of Oxidative Stress”, Sensors & Actuators: B. Chemical 255 (2018) 2194
> P. Singh, S. Choudhury, S. Kulanthaivel, D. Bagchi, I. Banerjee, S. A. Ahmed, and S. K. Pal
“Photo-triggered Destabilization of Nanoscopic Vehicles by Dihydroindolizine for Enhanced Anticancer Drug Delivery in Cervical Carcinoma”, Colloids and Surfaces B: Biointerfaces 162 (2018) 202
> A. Halder, P. K. Sarkar, P. Pal, S. Chakrabarti, P. Chakrabarti, D. Bhattacharyya, R. Chakraborty and S. K. Pal
“Digital Camera Based Spectrometry for the Development of Point-of-Care Anemia Detection on Ultra-low Volume Whole Blood Sample”, IEEE Sensors Journal 17 (2017) 7149.
> J. Patwari, S. Sardar, B. Liu, P. Lemmens and S. K. Pal
“Three in One Approach Towards Efficient Organic Dye Sensitized Solar Cells: Anti-aggregation, Panchromatic Absorption and Resonance Energy Transfer”, Beilstein J. Nanotechnology 8 (2017) 1705.
> P. K. Sarkar, A. Halder, N. Polley and S. K. Pal
“Development of Highly Selective and Efficient Prototype Sensor for Potential Application in Environmental Mercury Pollution Monitoring”, Water, Air, & Soil Pollution 228 (2017) 314.
> P. Kar, T. K. Maji, J. Patwari and S. K. Pal
“Can A Light Harvesting Material be Always Common in Photocatalytic and Photovoltaic Applications?”, Materials Chemistry and Physics 200 (2017) 70.
> A. Mazumder, S. Batabyal, M. Mondal, T. Mondol, S. Choudhury, R. Ghosh, T. Chatterjee, D. Bhattacharyya, S. K. Pal, and S. Roy “Specific DNA Sequences Allosterically Enhance Protein-Protein Interaction in a Transcription Factor through Modulation of Protein Dynamics: Implications for Specificity of Gene Regulation”, Phys. Chem. Chem. Phys. 19 (2017) 14781.
> R. Nandi, S. Mishra, T. K. Maji, K. Manna, P. Kara, S. Banerjee, S. Dutta, S. K Sharma, P. Lemmens, K. Das Saha and S. K. Pal “A Novel Nanohybrid for Cancer Theranostics: Folate Sensitized Fe2O3 Nanoparticle for Colorectal Cancer Diagnosis and Photodynamic Therapy”, J. Mat. Chem. B 5 (2017) 3927.
> P. Singh, S. Choudhury, S. Dutta, A. Adhikari, S. Bhattacharya, D. Pal and S. K. Pal
“Ultrafast Spectroscopy on DNA-Cleavage by Endonuclease in Molecular Crowding”, Int. J. Biol. Macromolecules 103 (2017) 395.
> P. K. Sarkar, S. Pal, N. Polley, R. Aich, A. Adhikari, A. Halder, S. Chakrabarti, P. Chakrabarti and S. K. Pal
“Development and Validation of a Noncontact Spectroscopic Device for Hemoglobin Estimation at Point-of-Care”, J. Biomed. Optics 22 (2017) 055006.
> P. Singh, S. Choudhury, S. Singha, Y. Jun, S. Chakraborty, J. Sengupta, R. Das, K-Han Ahn and S. K. Pal. “A Sensitive Fluorescence Probe for the Polar Solvation Dynamics at Protein- Surfactant Interface”, Phys. Chem. Chem. Phys. 19 (2017) 12237.
> D. Bagchi, S. Dutta, P. Singh, S. Chaudhuri and S. K. Pal. “Essential Dynamics of an Effective Phototherapeutic Drug in a Nanoscopic Delivery Vehicle: Psoralen in Ethosome for Biofilm Treatment”, ACS Omega 2 (2017) 1850.
> S. Mondal, A. Giri, Y. Zhang, S. K. Pal, W. Zhou and L-ping Wen “Caspase mediated beclin-1 dependent autophagy tuning activity and apoptosis promotion by surface modified hausmannite nanoparticle”, J. Biomed. Mat. Res.: A 105 (2017) 1299.
> A. Adhikari, N. Polley, S. Darbar and S. K. Pal “Therapeutic Potential of Surface Functionalized Mn3O4 Nanoparticles against Chronic Liver Diseases in Murine Model”, Materials Focus 3 (2017) 280.
> S. Ghosh, P. Kar, N. Bhandary, S. Basu, T. Maiyalagan, S. Sardar and S. K. Pal “Reduced graphene oxide supported hierarchical flower like manganese oxide as efficient electrocatalysts toward reduction and evolution of oxygen”, Int. J. Hydrogen Energy 42 (2017) 4111.
> Z. S. Seddigi, S. A. Ahmed, S. Sardar, N. H. Yarkandi, M. Abdulaziz and S. K. Pal “Combating Fuel-driven Aqua-Pollution by �BenzoMagnets�”, RSC Advances 7 (2017) 12277.
> D. Bagchi, T. K. Maji, S. Sardar, P. Lemmens, C. Bhattacharya, D. Karmakar and S. K. Pal “Sensitized ZnO Nanorod assemblies to detect heavy metal contaminated phytomedicines: Spectroscopic and Simulation Studies”, Phys. Chem. Chem. Phys. 19 (2017) 2503.
> T. K. Maji, D. Bagchi, P. Kar, D. Karmakar and S. K. Pal “Enhanced Charge Separation through Modulation of Defect-state in Wide Band-gap Semiconductor for Potential Photocatalysis Application: Ultrafast Spectroscopy and Computational Studies”, J. Photochem. Photobiol. A 332 (2017) 391.
> P. Kar, T. K. Maji, R. Nandi, P. Lemmens and S. K. Pal. “In-situ hydrothermal synthesis of Bi-Bi2O2CO3 heterojunction photocatalyst with enhanced visible light photocatalytic activity”, Nano-Micro Letters 9 (2017) 18.
> J. Patwari, H. Ghadi, S. Sardar, J. Singhal, B. Tongbram, S. Shyamal, C. Bhattacharya, S. Chakrabarti and S. K. Pal
“Photo-induced electronic properties in single quantum well system: Effect of excitonic lifetime”, Materials Res. Express 4 (2017) 016301.

Prof. Pal is associated with ‘Journal of Materials NanoScience’ as Editorial Advisory Board Member since 2014. The journal link is