Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (15a-15t) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut shell liquid (CNSL). All the newly synthesized compounds were screened for their in vitro antitumor activity. Baylis-Hillman compounds 5b and 5h showed promising anticancer activity against MCF-7. Among pyrimidine derivatives, compounds 15i, 15j and 15l showed promising activity against HEP-G2, whereas compounds 15j, 15k, 15l and 15m showed promising activity against MCF-7. In addition, compound 15m showed significant activity against K562 when compared with the standard. The structure-activity relationship (SAR) analysis suggests that the length of the carbon chain of phenyl ring played an important role in the potency of activity.
Professor Samir Kumar Pal,
Department of Chemical, Biological & Macromolecular Sciences,
S.N.Bose National Centre for Basic Sciences,
JD Block, Sector III, Salt Lake,
Kolkata (Calcutta), India
Expertise: Ultra-fast Spectroscopy in Bio molecules and Materials, Biomimetics, DSSC, Nanomedicines, Nano-catalysis, Development of Instruments for biomedical and environmental use.
> P. Kar, T. K. Maji, P. K. Sarkar, P. Lemmens and S. K. Pal. Development of a Photo-Catalytic Converter for Potential Use in the Detoxification of Cr(VI) Metal in Water from Natural Resources”, J. Mat. Chem. A (2018)
> P. K. Sarkar, A. Halder, A. Adhikari, N. Polley, S. Darbar, P. Lemmens and S. K. Pal
“DNA-based Fiber Optic Sensor for Direct In-vivo Measurement of Oxidative Stress”, Sensors & Actuators: B. Chemical 255 (2018) 2194
> P. Singh, S. Choudhury, S. Kulanthaivel, D. Bagchi, I. Banerjee, S. A. Ahmed, and S. K. Pal
“Photo-triggered Destabilization of Nanoscopic Vehicles by Dihydroindolizine for Enhanced Anticancer Drug Delivery in Cervical Carcinoma”, Colloids and Surfaces B: Biointerfaces 162 (2018) 202
> A. Halder, P. K. Sarkar, P. Pal, S. Chakrabarti, P. Chakrabarti, D. Bhattacharyya, R. Chakraborty and S. K. Pal
“Digital Camera Based Spectrometry for the Development of Point-of-Care Anemia Detection on Ultra-low Volume Whole Blood Sample”, IEEE Sensors Journal 17 (2017) 7149.
> J. Patwari, S. Sardar, B. Liu, P. Lemmens and S. K. Pal
“Three in One Approach Towards Efficient Organic Dye Sensitized Solar Cells: Anti-aggregation, Panchromatic Absorption and Resonance Energy Transfer”, Beilstein J. Nanotechnology 8 (2017) 1705.
> P. K. Sarkar, A. Halder, N. Polley and S. K. Pal
“Development of Highly Selective and Efficient Prototype Sensor for Potential Application in Environmental Mercury Pollution Monitoring”, Water, Air, & Soil Pollution 228 (2017) 314.
> P. Kar, T. K. Maji, J. Patwari and S. K. Pal
“Can A Light Harvesting Material be Always Common in Photocatalytic and Photovoltaic Applications?”, Materials Chemistry and Physics 200 (2017) 70.
> A. Mazumder, S. Batabyal, M. Mondal, T. Mondol, S. Choudhury, R. Ghosh, T. Chatterjee, D. Bhattacharyya, S. K. Pal, and S. Roy “Specific DNA Sequences Allosterically Enhance Protein-Protein Interaction in a Transcription Factor through Modulation of Protein Dynamics: Implications for Specificity of Gene Regulation”, Phys. Chem. Chem. Phys. 19 (2017) 14781.
> R. Nandi, S. Mishra, T. K. Maji, K. Manna, P. Kara, S. Banerjee, S. Dutta, S. K Sharma, P. Lemmens, K. Das Saha and S. K. Pal “A Novel Nanohybrid for Cancer Theranostics: Folate Sensitized Fe2O3 Nanoparticle for Colorectal Cancer Diagnosis and Photodynamic Therapy”, J. Mat. Chem. B 5 (2017) 3927.
> P. Singh, S. Choudhury, S. Dutta, A. Adhikari, S. Bhattacharya, D. Pal and S. K. Pal
“Ultrafast Spectroscopy on DNA-Cleavage by Endonuclease in Molecular Crowding”, Int. J. Biol. Macromolecules 103 (2017) 395.
> P. K. Sarkar, S. Pal, N. Polley, R. Aich, A. Adhikari, A. Halder, S. Chakrabarti, P. Chakrabarti and S. K. Pal
“Development and Validation of a Noncontact Spectroscopic Device for Hemoglobin Estimation at Point-of-Care”, J. Biomed. Optics 22 (2017) 055006.
> P. Singh, S. Choudhury, S. Singha, Y. Jun, S. Chakraborty, J. Sengupta, R. Das, K-Han Ahn and S. K. Pal. “A Sensitive Fluorescence Probe for the Polar Solvation Dynamics at Protein- Surfactant Interface”, Phys. Chem. Chem. Phys. 19 (2017) 12237.
> D. Bagchi, S. Dutta, P. Singh, S. Chaudhuri and S. K. Pal. “Essential Dynamics of an Effective Phototherapeutic Drug in a Nanoscopic Delivery Vehicle: Psoralen in Ethosome for Biofilm Treatment”, ACS Omega 2 (2017) 1850.
> S. Mondal, A. Giri, Y. Zhang, S. K. Pal, W. Zhou and L-ping Wen “Caspase mediated beclin-1 dependent autophagy tuning activity and apoptosis promotion by surface modified hausmannite nanoparticle”, J. Biomed. Mat. Res.: A 105 (2017) 1299.
> A. Adhikari, N. Polley, S. Darbar and S. K. Pal “Therapeutic Potential of Surface Functionalized Mn3O4 Nanoparticles against Chronic Liver Diseases in Murine Model”, Materials Focus 3 (2017) 280.
> S. Ghosh, P. Kar, N. Bhandary, S. Basu, T. Maiyalagan, S. Sardar and S. K. Pal “Reduced graphene oxide supported hierarchical flower like manganese oxide as efficient electrocatalysts toward reduction and evolution of oxygen”, Int. J. Hydrogen Energy 42 (2017) 4111.
> Z. S. Seddigi, S. A. Ahmed, S. Sardar, N. H. Yarkandi, M. Abdulaziz and S. K. Pal “Combating Fuel-driven Aqua-Pollution by �BenzoMagnets�”, RSC Advances 7 (2017) 12277.
> D. Bagchi, T. K. Maji, S. Sardar, P. Lemmens, C. Bhattacharya, D. Karmakar and S. K. Pal “Sensitized ZnO Nanorod assemblies to detect heavy metal contaminated phytomedicines: Spectroscopic and Simulation Studies”, Phys. Chem. Chem. Phys. 19 (2017) 2503.
> T. K. Maji, D. Bagchi, P. Kar, D. Karmakar and S. K. Pal “Enhanced Charge Separation through Modulation of Defect-state in Wide Band-gap Semiconductor for Potential Photocatalysis Application: Ultrafast Spectroscopy and Computational Studies”, J. Photochem. Photobiol. A 332 (2017) 391.
> P. Kar, T. K. Maji, R. Nandi, P. Lemmens and S. K. Pal. “In-situ hydrothermal synthesis of Bi-Bi2O2CO3 heterojunction photocatalyst with enhanced visible light photocatalytic activity”, Nano-Micro Letters 9 (2017) 18.
> J. Patwari, H. Ghadi, S. Sardar, J. Singhal, B. Tongbram, S. Shyamal, C. Bhattacharya, S. Chakrabarti and S. K. Pal
“Photo-induced electronic properties in single quantum well system: Effect of excitonic lifetime”, Materials Res. Express 4 (2017) 016301.
Prof. Pal is associated with ‘Journal of Materials NanoScience’ as Editorial Advisory Board Member since 2014. The journal link is http://www.pubs.iscience.in/journal/index.php/jmns