urn:nbn:sciencein.cbl.2019v6.107
Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity
Published in: Chemical Biology Letters
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Ashish Bhatt
Mewar University
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Krishna Srivastava
Shri Ramswaroop Memorial University
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Ravi Kant
Shri Ramswaroop Memorial University
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Deepa Lakhmani
Shri Ramswaroop Memorial University
Keywords:
4-methyl-1H-isochromen-1-one,
1,1-biphenyl-4,4-diamine, Antibacterial activity,
anti-microbial activity
Abstract
Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.
Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.
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