Medicinal Science – Page 2 – ScienceIn Publishing

Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review

urn:nbn:sciencein.jmns.2020.v7.99

Published in: Journal of Materials NanoScience

Parul Pant

University of Delhi
Dr. Chetna Gupta

University of Delhi
Sagar Kumar

Indian Institute of Science
Apoorva Grewal

University of Delhi
Shivani Garg

University of Delhi
Aishwarya Rai

University of Delhi

Keywords:

Silica, Nanoparticles,
trumeric, drug delivery, cancer,
diabetes, nanomedicine, biomedical science

Abstract

Silica nanoparticles offer a promising platform for the delivery of drugs, in particular for the drugs which lack water solubility, target capability and have non-specific distribution, systematic toxicity and low therapeutic index. In this review, we focus on the synthesis and therapeutic (particularly, anti-cancer) applications of Curcumin loaded Silica Nanoparticles. Various surface modifications of silica nanoparticles have been discussed that are used to enhance their therapeutic applications. The characterization techniques and study of their biocompatibility have also been presented.

Cite as: Pant, P., Gupta , C., Kumar, S., Grewal, A., Garg, S., & Rai, A. (2020). Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review. Journal of Materials NanoScience, 7(1), 1-18.

Retrieve full text from http://thesciencein.org/journal/index.php/jmns/article/view/99 and/or http://pubs.iscience.in/journal/index.php/jmns/article/view/989

Contemporary advances in therapeutic portfolio of 2-Azetidinones

URN:NBN:sciencein.cbl.2020.v7.98

Published in Chemical Biology Letters

Rajneesh Kaur

Maharishi Markandeshwar (Deemed to be University)
Dr. (Mrs.) Raman Singh

Maharishi Markandeshwar (Deemed to be University)
Priyanka Ahlawat

Maharishi Markandeshwar (Deemed to be University)
Parul Kaushik

Maharishi Markandeshwar (Deemed to be University)
Kuldeep Singh

Maharishi Markandeshwar University

Keywords:

β-lactams, monobactam,
antimicrobial drug resistance, biological activity,
multi target drugs

Abstract

The heterocycle moieties form the site of reaction in many enzymes and co-enzymes and also act as an important pharmacophore in the pharmaceutical drug designs. 2-Azetidinones are the 2-carbonyl derivatives of azetidine, more commonly known as β-lactams. These structural entities occupied a central role in the vigil against bacterial infections over the past few decades. A subclass of these heterocyclic systems, monobactams or monocyclic β-lactam derivatives exhibits several biological activities including antibacterial, antifungal, antiprotozoal, anti-mycobacterial, anti-HIV, antiviral, antimalarial, antioxidant, apoptotic inhibitors, anti-inflammatory activity, anticancer activity, herbicidal activity, etc. Monobactams has resistant to the β-lactamase enzyme and could be a reasonable starting point for developing new drugs or inhibitors. In the present review, pharmacological activities of monocyclic β-lactam derivatives have been discussed with respect to current research in the structure-activity relationships in different therapeutic areas.

Cite as: Rajneesh, K., Singh, R., Ahlawat, P., Kaushik, P., & Singh, K. (2020). Contemporary advances in therapeutic portfolio of 2-Azetidinones. Chemical Biology Letters, 7(1), 13-26.

Retrieved full text from http://thesciencein.org/journal/index.php/cbl/article/view/98 and/or http://www.pubs.iscience.in/journal/index.php/cbl/article/view/987

Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)

urn:nbn:sciencein.cbl.2020.v7.96

Published in: Chemical Biology Letters

Pooja Mittal

University of Delhi
Sujata Singh

University of Delhi
Archana Singh

University of Delhi
Indrakant K. Singh

University of Delhi

Keywords: Drug delivery, Nanomedicine, Nanobiotechnology, Liposome, Nanoparticles, Hydrogels, Aptamer

Abstract

Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.

Cite as: Mittal, P.; Singh, S.; Singh, A.; Singh, I. K. Current Advances in Drug Delivery Systems for Treatment of Triple Negative Breast Cancer (TNBC). Chem Biol Lett 2020, 7(1), 1-12.

Retrieve Full text from:

http://www.pubs.iscience.in/journal/index.php/cbl/article/view/941

http://thesciencein.org/journal/index.php/cbl/article/view/96

Current Pharmaceutics

Announcing the new journal for pharmaceuticals sciences covering

pharmaceutical chemistry,
medicinal chemistry,
pharmacology,
toxicology,
drug evaluation,
pharmaceutical sciences,
drug development,
regulatory affairs,
drug delivery,
clinical studies, and
all aspects of pharmaceuticals and therapeutics sciences.

Type: International, Peer review

Start Year: 2020/21

See more details about journal and submission at

http://thesciencein.org/journal/index.php/cp

Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice

urn:nbn:sciencein.cbl.2019.v6.115

Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice

Published in: Chemical Biology Letters

Suman Devi

Maharshi Dayanand University
Jagjeet Singh

Maharshi Dayanand University
Vijay Kumar

Maharshi Dayanand University
Vinay Malik

Maharshi Dayanand University

Keywords:

histopathology, oxidative stress,
kidney, lipid peroxidation, toxicology

Abstract

The present study investigated the effect of monocrotophos, a commonly used organophosphate pesticide exposure in the kidney tissues of the swiss albino mice. Monocrotophos was administered at the sub-lethal doses of 1.25mg/kg, 2.5 mg/kg and 5.0 mg/kg body weight for 24 hr. Monocrotophos toxicity generated oxidative stress in the mice as evidenced by significant decrease in the activities of glutathione, superoxide dismutase and catalase enzymes. The exposure increased the lipid peroxidation and protein oxidation in a dose dependent manner. Oxidative stress generation also elicited cytotoxic effects on the mice kidney which were supported by the histopathological changes like degeneration in glomerulus, bowmen’s capsule and tubules, hemorrhage, mononuclear cell infiltration, tubular cast and congested blood vessels in a dose-dependent manner. In conclusion, the study indicated that monocrotophos exposure at various doses induces significant deleterious health effects in mice kidney tissues via oxidative stress generation.

Cite as: Devi, S., Singh, J., Kumar, V., & Malik, V. (2019). Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice. Chemical Biology Letters, 6(2), 39-45.

Retrieved full text from http://pubs.thesciencein.org/journal/index.php/cbl/article/view/115