Solvent free synthesis of 1,5-benzodiazepines catalyzed by zirconium nitrate

ISSN 2348-1889

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Solvent free synthesis of 1,5-benzodiazepines catalyzed by zirconium nitrate

Ambika¹ Pradeep Pratap Singh^2*

¹ Department of Chemistry, Hansraj College, University of Delhi, Delhi-110007, India; ²Department of Chemistry, Swami Shraddhanand College, University of Delhi, Delhi-110036, India.

1,5-benzodiazepines are synthesized by the condensation of o-phenylenediamine and various ketones in the presence of Zr(NO₃)₄ under solvent free condition. The method offers mild reaction conditions, less reaction time, easy workup, high  yields, easy product isolation, selectivity of the reaction and reusability of catalyst.

Keywords: Benzodiazepines, Solvent free, Zirconium nitrate