Chemical Biology Letters

Chemical Biology LettersEditors
Prof. Keykavous Parang
Chapman University Editor (USA)
Dr. B.S. Chhikara,
University of Rhode Island Executive Managing Editor
Dr. R. Dabur,
M.D. University Associate Editor (India)
ISSN 2347–9825
The Chemical Biology Letter is an international journal that provides a rapid forum for publication of quality original research at the interface of chemistry and biology. Chemical biology letters covers the scientific ideas and approaches of chemistry, biology and allied interdisciplinary areas such as medicinal chemistry, drug discovery, drug delivery, biosensor, protein chemistry, biological chemistry, biomolecules, bio-technology, biomedical, molecular biology and other allied areas covering chemistry and biology for better understanding of biological phenomenon at molecular level. The journal invite research articles from the community of chemical biologists.

Chemical Biology Letters is now indexed in WHO’s HINARI (see details at Chemical Biology Letters on HINARI ).
See Five selected articles in Medicinal Chemistry / Biomedical Sciences

Recent ArticlesNews

2017 Vol 4 Issue 2

Synthesis, characterization and antimicrobial evaluation of benzimidazole clubbed benzothiazole derivatives
Prabodh Chander Sharma, Seema Padwal, Anil Saini, Kushal Bansal
Chem. Biol. Lett., 2017, 4(2), 63-68

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Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria
Sridevi Dhanarani, Shankar Congeevaram, Prakash Piruthiviraj, Joon Hong Park, Thamaraiselvi Kaliannan
Chem. Biol. Lett., 2017, 4(2), 69-72

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Synthesis, antimicrobial and antimalarial study of novel 1,3,4-thiadiazole derivatives incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties
Ashish Bhatt, Rajesh Kumar Singh, Ravi Kant
Chem. Biol. Lett., 2017, 4(2), 73-80

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Synthesis of novel 2-(3-aryl/alkylamino propoxy)-12-aryl xanthene derivatives as antifungal and antibacterial agents
Bhaskara Nand, Kalawati Meena, Shruti Gupta, J.M. Khurana, Amita Malik, Chetan Sharma, Harsh Panwar
Chem. Biol. Lett., 2017, 4(2), 81-90

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2017 Vol 4 Issue 1

Development and validation of pharmacophore and QSAR models for influenza PB2 inhibitors
Deepak Kumar Behera, Pabitra Mohan Behera, Laxmikanta Acharya, Anshuman Dixit
Chem. Biol. Lett., 2017, 4(1), 1-8

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Fighting with Gram-negative enemy: Can outer membrane proteins aid in the rescue?
Anubhav Tamrakar, Amit Kumar Singh, Meenal Chodhrary, Prashant Kodgire
Chem. Biol. Lett., 2017, 4(1), 9-19

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Identification of immunodominant epitopes in the HA2 subunit of H5N1 haemagglutinin by immunoassay using synthetic peptides as antigens
Khangembam Victoria Chanu, Dimpal Thakuria, Richa Sood, Atul K Pateriya, Sandeep Bhatia, Satish Kumar
Chem. Biol. Lett., 2017, 4(1), 20-26

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Homology modeling and docking studies of VP24 protein of Ebola virus with an antiviral drug and its derivatives
Deepti Sharma, Navneet sharma, Mallika Pathak, Riya Sharma, Prateek Tyagi, Raman Chawla, Mitra Basu, Himanshu Ojha
Chem. Biol. Lett., 2017, 4(1), 27-32

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Trials and tribulations in tuberculosis research: Can plant based drug(s) be the solution?
Smita Mishra, Manisha Khatri, Varsha Mehra
Chem. Biol. Lett., 2017, 4(1), 33-47

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Antimicrobials in Higher Plants: classification, mode of action and bioactivities
Ishwar Singh
Chem. Biol. Lett., 2017, 4(1), 48-62

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2016 Vol 3 Issue 2

Application of Porphyrin nanomaterials in Photodynamic therapy
Pratibha Kumari, Renu Gautam, Archana Milhotra
Chem. Biol. Lett., 2016, 3(2), 32-37
Porphyrin Nanoparticles
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Synthesis of novel Imidazo [1,2-b] pyridazine derivatives and study of their biomedicinal efficacy
Ashish Bhatt, Rajesh Kumar Singh, Ravi Kant
Chem. Biol. Lett., 2016, 3(2), 38-43

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Morin augmented the metabolism and detoxification of ethanol: effects on TGF-β and the collagen accumulation
Saravanan Nadanam, Anbu Singaravelu, Padma Jayabalan, Niyas Ahamed Md Iqbal
Chem. Biol. Lett., 2016, 3(2), 44-51

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Synthesis, characterization and evaluation of prodrugs of ciprofloxacin clubbed with benzothiazoles through N-Mannich base approach
Mona Piplani, Avtar Chand Rana, Prabodh Chander Sharma
Chem. Biol. Lett., 2016, 3(2), 52-57

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Biosystematics of the Dioscorea species of western ghats using chemical and molecular tools
A. Rafeeq, K.B. Rameshkumar, N.S. Pradeep
Chem. Biol. Lett., 2016, 3(2), 58-63

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2016 Vol 3 Issue 1

An overview of lignans with special reference to podophyllotoxin, a cytotoxic lignan
Saptarshi Hazra, Sharmila Chattopadhyay
Chem. Biol. Lett., 2016, 3(1), 1-8
lignans podophyllotoxins
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Chemical Evolution and Origin of Life: A Review
Avnish Kumar Arora, Kuldeep Singh, Vivek Sheel Jaswal, Raman Singh
Chem. Biol. Lett., 2016, 3(1), 9-17
Evolution of life
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1,5-Benzothiazepine: Bioactivity and targets
Rajneesh Kaur, Raman Singh, Kuldeep Singh
Chem. Biol. Lett., 2016, 3(1), 18-31

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2015 Vol 2 Issue 2

Recent advances in development of Inhibitors of Dengue infection
Poonam Bhargava, Nisha Aggarwal
Chem. Biol. Lett., 2015, 2(2), 22-29
Dengue inhibitor drugs
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Liesegang patterns, growth kinetics, inhibition and dissolution of calcium phosphate: A constituent of renal stone
Alpana Tripathi, Gopal ji Srivastavaa, Sashank Srivastava, Ishwar Das
Chem. Biol. Lett., 2015, 2(2), 30-40
calcium phosphate crystal formation
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Comparative study of antibacterial activity of standard antibiotic with silver nanoparticles synthesized using ocimum tenuiflorum and garcinia mangostana leaves
Nikesh Gupta, Chetna Gupta, Sandeep Sharma, Rakesh Kumar Sharma, H. B. Bohidar
Chem. Biol. Lett., 2015, 2(2), 41-44
nanoparticle synthesis
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2015 Vol 2 Issue 1

Evaluation of inhibition of protein tyrosine phosphatase 1B by calixarene-based α-ketophosphonic acids
Viacheslav Trush, Sergiy Cherenok, Vsevolod Tanchuk, Vitaly Kalchenko, Andriy Vovk
Chem. Biol. Lett., 2015, 2(1), 1-5
Calixarene-kinase docking
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Evaluation of anti-hyperglycemic effect of Gracilaria corticata extract in Normal and Streptozotocin-induced Diabetic rats
Subashini Sekar, Pugalendi Viswanathan K, Baskaran Kishnan, Kripa Kavasseri Ganesan
Chem. Biol. Lett., 2015, 2(1), 6-11
anti-diabetic effect of plant extract
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Characterization of podophyllotoxin biosynthetic pathway and future prospect of podophyllotoxin production from Podophyllum hexandrum Royle
Dipto Bhattacharyya, Sharmila Chattopadhyay
Chem. Biol. Lett., 2015, 2(1), 12-21
podophyllotoxin biosynthetic pathway
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2014 Vol 1 Issue 2

Effects of 1,3-di-O-substituted-myo-inositol derivatives on the antiproliferation and caspase-3 activity of HCT-116 and HL-60 cells
Noriyuki Hatae, Satoe Yamauchi, Takafumi Saeki, Ichiro Suzuki, Tominari Choshi, Satoshi Hibino, Chiaki Okada, Yutaka Watanabe, Eiko Toyota
Chem. Biol. Lett., 2014, 1(2), 40-43

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3D-QSAR and molecular docking studies of ATP-competitive Akt inhibitors with the scaffold 4-(piperazin-1-yl)pyrimidine
Xie Wencheng, Zhang Linna, Yin Yanzhen, Yang Dezhi, Zhao Guisen
Chem. Biol. Lett., 2014, 1(2), 44-54

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Recent advances in PET imaging of folate receptor positive diseases
Qingshou Chen, Ping Wang, Philip S Low, Sumith A Kularatne
Chem. Biol. Lett., 2014, 1(2), 55-65

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Control of carbohydrate and lipid metabolism by NRF-1 and sirtuins: Implications on type 2 diabetes and obesity
Zane Ferreira, Ademola Ayeleso, Emmanuel Mukwevho
Chem. Biol. Lett., 2014, 1(2), 66-76

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Perspectivity of bifunctional chelating agents in chemical, biological and biomedical applications
Bhupender S. Chhikara, Sumit Kumar, Nidhi Jain, Anil Kumar, Rajiv Kumar
Chem. Biol. Lett., 2014, 1(2), 77-103

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2014 Vol 1 Issue 1

Calmodulin dependent protein kinase (CaMK)-II activation by exercise regulates omega-3 polyunsaturated fatty acids biosynthesis in rat skeletal muscle
Jitcy S Joseph, Emmanuel Mukwevho
Chem. Biol. Lett., 2014, 1(1), 1-10

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Tetrahedral Hydroxyethylamine: A Privileged Scaffold in Development of Antimalarial Agents
Brijesh Rathi, Ph.D., Prem Prakash Sharma, R P Singh
Chem. Biol. Lett., 2014, 1(1), 11-13

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Comparative global epidemiology of HIV infections and status of current progress in treatment
Jyoti Singh, Bhupender S. Chhikara
Chem. Biol. Lett., 2014, 1(1), 14-32

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Monoamine Oxidase Inhibitors for Neurological Disorders: A review
Ram Singh, Geetanjali ., Naveen Sharma
Chem. Biol. Lett., 2014, 1(1), 33-39

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Text Abst

Earlier
In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, [...]
Source: Chem Biol Lett
In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also [...]
Source: Chem Biol Lett
A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H- benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. Structures have been confirmed by spectroscopic analysis. All the newly [...]
Source: Chem Biol Lett
A new class of 1,3,4-thiadiazole derivatives 8a-i incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties were synthesized by the reaction of arylidene derivatives of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety (Schiff base) 7a-i with thioglycolic acid. Schiff base 7a-i were synthesized by the reaction of 1,3,4-thiadiazoles 2-amine having imidazo [...]
Source: Chem Biol Lett
Antibiotic resistant bacteria (ABR) is an alarming issue and it has to be eliminated before enter into the environment. The role of efflux pump inhibitor, reserpine – a plant alkaloid in reducing the antibiotic resistance in Staphylococcus sp., Streptococcus sp. and Micrococcus sp. from poultry litter were evaluated. [...]
Source: Chem Biol Lett
A new series of N-(6-methoxybenzo[d]thiazol-2-yl)-2-substituted phenyl-1H-benz[d]imidazole-1-carbothioamide derivatives (5a-5h) has been synthesized and evaluated for antibacterial, antifungal and antimalarial effects. All these compounds were characterized and screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Titled compounds were also evaluated for their antimalarial activity against P. falciparum. [...]
Source: Chem Biol Lett
Plants produce an enormous number of phytochemicals as a part of their primary as well as secondary metabolism of those many could be of therapeutic value especially antimicrobial application to human beings. Majority of the isolated antimicrobials pertain to chemical groups namely, phenolics, terpenes, alkaloids and polypeptides, and exhibit multiple [...]
Source: Chem Biol Lett
The Swine influenza is a highly contagious respiratory disease caused by one of several swine influenza A viruses. The viral replication complex of H1N1, formed by three proteins PA, PB1 and PB2, plays a major role in host adaptation and subsequent infection. The conserved interaction sites of these three proteins [...]
Source: Chem Biol Lett
Outer membrane proteins (OMPs) are distinctive features of Gram-negative bacteria. Apart from their structural role, they play a crucial role in host pathogen interaction, virulence and pathogenesis of bacteria. Upon interaction with the host immune cells, OMPs stimulate production of proinflammatory molecules that may result in an uncontrolled inflammation, leading [...]
Source: Chem Biol Lett
An outburst of Ebola Hemorrhagic Fever (EHF) in recent years is a challenge towards health preparedness of India. Oseltamivir is the only frontline drug used in the treatment of Ebola hemorrhagic fever. In order to enhance preparedness again Ebola virus induced fever it is required to identify more derivatives with [...]
Source: Chem Biol Lett
Earlier
The Journal for NanoScience and Nanotechnology Education or Nanoeducation literature have been included in section part of ‘Journal of Materials NanoScience‘ under NanoEdu section. The faculty members now can published their literary work required for teaching and learning of NanoScience and Nanotechnology concepts. The following type of work will be [...]
Source: ISP Updates
In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, or [...]
Source: ISP Updates
In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also [...]
Source: ISP Updates
Dr. Brijesh Rathi, Department of Chemistry, Hansraj College, University of Delhi, Delhi-110007. India webpage: http://hansrajcollege.ac.in/faculty-info.php?id=28 Research Interests: Medicinal Chemistry, Maleria, Drug development, synthetic organic chemistry, peptide chemistry, peptide drugs, nanomedicine. Dr. Brijesh Rathi is a faculty of Chemistry in Hansraj College, University of Delhi and associated with Chemical Biology Letters [...]
Source: ISP Updates
Carmela Saturnino Prof. in Medicinal Chemistry Department of Science University of Basilicata viale dell'Ateneo Lucano Potenza ITALY Research Interest: Medicinal Chemistry Prof. Saturnino is Professor of Medicinal Chemistry in University of Basilicata, Italy and associated with Chemical Biology Letters ( http://pubs.iscience.in/journal/index.php/cbl/pages/view/editorialboard ) as Editorial Advisory Board Member. [...]
Source: ISP Updates

 

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