Chemical Biology Letters

Chemical Biology LettersEditors
Prof. Keykavous Parang
Chapman University Editor (USA)
Dr. B.S. Chhikara,
University of Rhode Island Executive Managing Editor
Dr. R. Dabur,
M.D. University Associate Editor (India)
ISSN 2347–9825
The Chemical Biology Letter is an international journal that provides a rapid forum for publication of quality original research at the interface of chemistry and biology. Chemical biology letters covers the scientific ideas and approaches of chemistry, biology and allied interdisciplinary areas such as medicinal chemistry, drug discovery, drug delivery, biosensor, protein chemistry, biological chemistry, biomolecules, bio-technology, biomedical, molecular biology and other allied areas covering chemistry and biology for better understanding of biological phenomenon at molecular level. The journal invite research articles from the community of chemical biologists.

Chemical Biology Letters is now indexed in WHO’s HINARI (see details at Chemical Biology Letters on HINARI ).
See Five selected articles in Medicinal Chemistry / Biomedical Sciences

Recent ArticlesNews

2017 Vol 4 Issue 2

Synthesis, characterization and antimicrobial evaluation of benzimidazole clubbed benzothiazole derivatives
Prabodh Chander Sharma, Seema Padwal, Anil Saini, Kushal Bansal
Chem. Biol. Lett., 2017, 4(2), 63-68

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Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria
Sridevi Dhanarani, Shankar Congeevaram, Prakash Piruthiviraj, Joon Hong Park, Thamaraiselvi Kaliannan
Chem. Biol. Lett., 2017, 4(2), 69-72

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Synthesis, antimicrobial and antimalarial study of novel 1,3,4-thiadiazole derivatives incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties
Ashish Bhatt, Rajesh Kumar Singh, Ravi Kant
Chem. Biol. Lett., 2017, 4(2), 73-80

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Synthesis of novel 2-(3-aryl/alkylamino propoxy)-12-aryl xanthene derivatives as antifungal and antibacterial agents
Bhaskara Nand, Kalawati Meena, Shruti Gupta, J.M. Khurana, Amita Malik, Chetan Sharma, Harsh Panwar
Chem. Biol. Lett., 2017, 4(2), 81-90

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2017 Vol 4 Issue 1

Development and validation of pharmacophore and QSAR models for influenza PB2 inhibitors
Deepak Kumar Behera, Pabitra Mohan Behera, Laxmikanta Acharya, Anshuman Dixit
Chem. Biol. Lett., 2017, 4(1), 1-8

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Fighting with Gram-negative enemy: Can outer membrane proteins aid in the rescue?
Anubhav Tamrakar, Amit Kumar Singh, Meenal Chodhrary, Prashant Kodgire
Chem. Biol. Lett., 2017, 4(1), 9-19

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Identification of immunodominant epitopes in the HA2 subunit of H5N1 haemagglutinin by immunoassay using synthetic peptides as antigens
Khangembam Victoria Chanu, Dimpal Thakuria, Richa Sood, Atul K Pateriya, Sandeep Bhatia, Satish Kumar
Chem. Biol. Lett., 2017, 4(1), 20-26

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Homology modeling and docking studies of VP24 protein of Ebola virus with an antiviral drug and its derivatives
Deepti Sharma, Navneet sharma, Mallika Pathak, Riya Sharma, Prateek Tyagi, Raman Chawla, Mitra Basu, Himanshu Ojha
Chem. Biol. Lett., 2017, 4(1), 27-32

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Trials and tribulations in tuberculosis research: Can plant based drug(s) be the solution?
Smita Mishra, Manisha Khatri, Varsha Mehra
Chem. Biol. Lett., 2017, 4(1), 33-47

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Antimicrobials in Higher Plants: classification, mode of action and bioactivities
Ishwar Singh
Chem. Biol. Lett., 2017, 4(1), 48-62

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2016 Vol 3 Issue 2

Application of Porphyrin nanomaterials in Photodynamic therapy
Pratibha Kumari, Renu Gautam, Archana Milhotra
Chem. Biol. Lett., 2016, 3(2), 32-37
Porphyrin Nanoparticles
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Synthesis of novel Imidazo [1,2-b] pyridazine derivatives and study of their biomedicinal efficacy
Ashish Bhatt, Rajesh Kumar Singh, Ravi Kant
Chem. Biol. Lett., 2016, 3(2), 38-43

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Morin augmented the metabolism and detoxification of ethanol: effects on TGF-β and the collagen accumulation
Saravanan Nadanam, Anbu Singaravelu, Padma Jayabalan, Niyas Ahamed Md Iqbal
Chem. Biol. Lett., 2016, 3(2), 44-51

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Synthesis, characterization and evaluation of prodrugs of ciprofloxacin clubbed with benzothiazoles through N-Mannich base approach
Mona Piplani, Avtar Chand Rana, Prabodh Chander Sharma
Chem. Biol. Lett., 2016, 3(2), 52-57

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Biosystematics of the Dioscorea species of western ghats using chemical and molecular tools
A. Rafeeq, K.B. Rameshkumar, N.S. Pradeep
Chem. Biol. Lett., 2016, 3(2), 58-63

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2016 Vol 3 Issue 1

An overview of lignans with special reference to podophyllotoxin, a cytotoxic lignan
Saptarshi Hazra, Sharmila Chattopadhyay
Chem. Biol. Lett., 2016, 3(1), 1-8
lignans podophyllotoxins
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Chemical Evolution and Origin of Life: A Review
Avnish Kumar Arora, Kuldeep Singh, Vivek Sheel Jaswal, Raman Singh
Chem. Biol. Lett., 2016, 3(1), 9-17
Evolution of life
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1,5-Benzothiazepine: Bioactivity and targets
Rajneesh Kaur, Raman Singh, Kuldeep Singh
Chem. Biol. Lett., 2016, 3(1), 18-31

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2015 Vol 2 Issue 2

Recent advances in development of Inhibitors of Dengue infection
Poonam Bhargava, Nisha Aggarwal
Chem. Biol. Lett., 2015, 2(2), 22-29
Dengue inhibitor drugs
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Liesegang patterns, growth kinetics, inhibition and dissolution of calcium phosphate: A constituent of renal stone
Alpana Tripathi, Gopal ji Srivastavaa, Sashank Srivastava, Ishwar Das
Chem. Biol. Lett., 2015, 2(2), 30-40
calcium phosphate crystal formation
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Comparative study of antibacterial activity of standard antibiotic with silver nanoparticles synthesized using ocimum tenuiflorum and garcinia mangostana leaves
Nikesh Gupta, Chetna Gupta, Sandeep Sharma, Rakesh Kumar Sharma, H. B. Bohidar
Chem. Biol. Lett., 2015, 2(2), 41-44
nanoparticle synthesis
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2015 Vol 2 Issue 1

Evaluation of inhibition of protein tyrosine phosphatase 1B by calixarene-based α-ketophosphonic acids
Viacheslav Trush, Sergiy Cherenok, Vsevolod Tanchuk, Vitaly Kalchenko, Andriy Vovk
Chem. Biol. Lett., 2015, 2(1), 1-5
Calixarene-kinase docking
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Evaluation of anti-hyperglycemic effect of Gracilaria corticata extract in Normal and Streptozotocin-induced Diabetic rats
Subashini Sekar, Pugalendi Viswanathan K, Baskaran Kishnan, Kripa Kavasseri Ganesan
Chem. Biol. Lett., 2015, 2(1), 6-11
anti-diabetic effect of plant extract
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Characterization of podophyllotoxin biosynthetic pathway and future prospect of podophyllotoxin production from Podophyllum hexandrum Royle
Dipto Bhattacharyya, Sharmila Chattopadhyay
Chem. Biol. Lett., 2015, 2(1), 12-21
podophyllotoxin biosynthetic pathway
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2014 Vol 1 Issue 2

Effects of 1,3-di-O-substituted-myo-inositol derivatives on the antiproliferation and caspase-3 activity of HCT-116 and HL-60 cells
Noriyuki Hatae, Satoe Yamauchi, Takafumi Saeki, Ichiro Suzuki, Tominari Choshi, Satoshi Hibino, Chiaki Okada, Yutaka Watanabe, Eiko Toyota
Chem. Biol. Lett., 2014, 1(2), 40-43

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3D-QSAR and molecular docking studies of ATP-competitive Akt inhibitors with the scaffold 4-(piperazin-1-yl)pyrimidine
Xie Wencheng, Zhang Linna, Yin Yanzhen, Yang Dezhi, Zhao Guisen
Chem. Biol. Lett., 2014, 1(2), 44-54

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Recent advances in PET imaging of folate receptor positive diseases
Qingshou Chen, Ping Wang, Philip S Low, Sumith A Kularatne
Chem. Biol. Lett., 2014, 1(2), 55-65

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Control of carbohydrate and lipid metabolism by NRF-1 and sirtuins: Implications on type 2 diabetes and obesity
Zane Ferreira, Ademola Ayeleso, Emmanuel Mukwevho
Chem. Biol. Lett., 2014, 1(2), 66-76

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Perspectivity of bifunctional chelating agents in chemical, biological and biomedical applications
Bhupender S. Chhikara, Sumit Kumar, Nidhi Jain, Anil Kumar, Rajiv Kumar
Chem. Biol. Lett., 2014, 1(2), 77-103

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2014 Vol 1 Issue 1

Calmodulin dependent protein kinase (CaMK)-II activation by exercise regulates omega-3 polyunsaturated fatty acids biosynthesis in rat skeletal muscle
Jitcy S Joseph, Emmanuel Mukwevho
Chem. Biol. Lett., 2014, 1(1), 1-10

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Tetrahedral Hydroxyethylamine: A Privileged Scaffold in Development of Antimalarial Agents
Brijesh Rathi, Ph.D., Prem Prakash Sharma, R P Singh
Chem. Biol. Lett., 2014, 1(1), 11-13

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Comparative global epidemiology of HIV infections and status of current progress in treatment
Jyoti Singh, Bhupender S. Chhikara
Chem. Biol. Lett., 2014, 1(1), 14-32

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Monoamine Oxidase Inhibitors for Neurological Disorders: A review
Ram Singh, Geetanjali ., Naveen Sharma
Chem. Biol. Lett., 2014, 1(1), 33-39

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Text Abst

Earlier
Type-2 diabetes mellitus (T2DM) is a global disease, which leads to various other life threatening diseases and affects the quality of life. Current therapies of T2DM have various side effects and ultimately lead to insulin resistance, along with financial burden. Therefore, comparative study of natural compounds along with their mechanisms [...]
Source: Chem Biol Lett
In a preliminary screening we found that few substituted benzaldehyde have growth inhibitory effect against Mycobacterium. Study was planned to convert these substituted benzaldehyde to antimycobacterial Schiff's bases. Schiff's bases were synthesized by condensation of 2-Amino pyridine/ its derivative or Thiophene/ Furoic/ Nicotinic acid hydrazide with these substituted benzaldehydes. Compounds [...]
Source: Chem Biol Lett
Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (15a-15t) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut [...]
Source: Chem Biol Lett
Guest Editorial for special issue on Nuclear Medicine [...]
Source: Chem Biol Lett
The current concepts of cancer therapy are moving towards personalized treatment regimen aiming to reduce toxicity and improve efficacy of therapeutic agents. With the development of molecular imaging and targeted therapies personalized care has received a shot in the arm. However, these developments are not without challenges. Drug delivery, metabolism, [...]
Source: Chem Biol Lett
Hyperparathyroidism (HPTH) is a condition in which the level of parathyroid hormone in blood is raised. Gold standard for the diagnosis of HPTH is a measurement of serum parathyroid hormone levels, accompanied by testing serum calcium levels, to differentiate between primary and secondary HPTH. The first line of treatment with [...]
Source: Chem Biol Lett
In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, [...]
Source: Chem Biol Lett
In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also [...]
Source: Chem Biol Lett
A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H- benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. Structures have been confirmed by spectroscopic analysis. All the newly [...]
Source: Chem Biol Lett
A new class of 1,3,4-thiadiazole derivatives 8a-i incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties were synthesized by the reaction of arylidene derivatives of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety (Schiff base) 7a-i with thioglycolic acid. Schiff base 7a-i were synthesized by the reaction of 1,3,4-thiadiazoles 2-amine having imidazo [...]
Source: Chem Biol Lett
Earlier
#NanoCatalysis covers the development in new #chemistry for #nanocatalysts synthesis and applications. The chemistry in the field of nanocatalysis and nanocatalysts is advancing at a fast pace, #high-impact and bringing the new methodologies, chemical procedures for synthesis of nanocatalysts along with development of new type of nanocatalysts. The application field [...]
Source: ISP Updates
Nanomaterials Frontiers is meant to cover exciting new and recent research advances in field of nanomaterials, smart materials development, new notable technological advances at nanometer scale research and path breaking research finding in nanomaterials advances. The Frontier research in nanomaterials covered from all literary sources highlighted as breakthrough findings in [...]
Source: ISP Updates
urn:nbn:sciencein.jmns.2018v5.60 Synthesis and Biodegradation Study of Starch/PVA/Nanoclay Blend Geeta Saini University of Delhi Himani Chauhan University of Delhi Aeshna Gupta University of Delhi Disha Gangotia University of Delhi Keywords: Food packaging, Nanoclay, Biodegradable, PVA, Starch Abstract In this research work, we have synthesized blend of starch/PVA/nanoclay via solution cast method. [...]
Source: ISP Updates
urn:nbn:sciencein.jmns.2018v5.61 Herbal nanomedicine interactions to enhance pharmacokinetics, pharmaco-dynamics, and therapeutic index for better bioavailability and biocompatibility of herbal formulations Rajiv Kumar University of Delhi Munesh Sharma Arogya Nidhi Ayurveda Clinic Keywords: Phyto-medicine, Hydrophilicity, Nanocarriers, Drug Delivery Abstract The recent technological advancement in nanotechnology has opened new avenues for research and [...]
Source: ISP Updates
The recent technological advancement in nanotechnology has unlocked new avenues for research and development in the field of phyto-medicine. Development of reliable and eco-friendly synthesis of nanoparticles is a significant advancement for starter nanotechnology to develop noble nanomedical delivery system of herbs (HNMDS), and have to overcome the downsides of [...]
Source: ISP Updates

 

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