Horner-Wadsworth-Emmons olefination useful for the stereoselective total synthesis of antifungal (R)-4-Methoxydecanoic Acid

Abstract

The stereoselective total synthesis of novel antifungal (R)-4-methoxydecanoic acid has been accomplished. The chiral centre was developed using D-Proline catalyzed asymmetric α-aminoxylation reaction. Synthesis was completed in four steps with good overall yield 46% and optical purity is up to 95% ee.