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A Concise Review on Cyclin Dependent Kinase 5 (CDK5) Inhibitors

Amit Kumar Gautam

Abstract


Cyclin dependent kinases 5 (CDK5) carry out many critical roles in the process of cell cycling and play an important role in many physiological functions, including development of central nervous system and their inhibitors have been extensively researched as therapeutic agents in the diagnosis of cancer. CDK5 belongs to Serine/Threonine Cyclin-dependent kinase (cdk) family. CDK5/ p25 complex has emerged as one of the potent principle therapeutic target for various diseases like acute and chronic neurodegenerative disease, including Alzheimer’s disease. Excessive upregulation of CDK5 leads to several types of neurodegenerative disorders like Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Niemann pick type C disease and Ischemia. To inhibit the excessive activity of cdk5, several cdk5 inhibitors have been synthesized and discovered naturally by various research groups globally here in this review we are accounting some of them together to show their efficacy.

Keywords


Cyclin dependent kinase; Cdk; Serine; Threonine; Alzheimer’s disease; ALS; Ischemia

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