niosome of quercetin

Niosomal formulation of Quercetin and Resveratrol and in-vitro release studies

Nivetha Murugesan, Chandraprabha Damodaran, Selvakumar Krishnamoorthy


Dietary polyphenols from plant origins play a major role in the human diet. They supply efficient antioxidants that reduce or prevent ROS production depending on the concentration. However, these polyphenols are less bio-available in the body due to various parameters, including low intrinsic activity, poor absorption, high metabolism, inactivity of metabolic products, and/or rapid elimination. Quercetin and resveratrol are dietary polyphenols that are often found in the human diet. However, they lag in bioavailability, which makes them less preferred nutraceuticals. This particular study is aimed at increasing the bioavailability of quercetin and resveratrol through the nano vector system, niosomes. In this study, niosomes entrapped with Quercetin and Resveratrol were produced in different concentrations of Span 60 and cholesterol using the thin film hydration method. The best suitable composition, which provides maximum entrapment, was taken for further study. The niosomal formulation of quercetin and resveratrol was evaluated using various methods like solubility and shape. The entrapment efficiency was determined to be 61.55%. The niosomes were then characterized using a zeta sizer and a potential. The average particle size of niosomes was 194 diameter values in nanometers, and their zeta potential was -20 mV, which indicated their good stability. The results of the in vitro drug release research, which was conducted using phosphate buffer saline pH 7.4, were that 92.6% in 24 hours was significantly increased compared to quercetin and resveratrol release, 71.30%. The ex vivo drug release was 94.5% after 24 hours, which was higher when compared to quercetin and resveratrol release of 75.74%. The results of this study indicate that the niosomes significantly enhanced the bioavailability of quercetin and resveratrol.


Quercetin; Resveratrol; Bioavailability; Niosomes; Drug release;

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