Antiquorum sensing activity of selected Eritrean traditional medicinal plants against Pseudomonas aeruginosa

Abstract

The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. In this study three different assays were performed; Las-A staphylolytic assay, anti-swarming assay, pyocyanin assay. In the anti-swarming activity, the highest anti-swarming activity were seen in the chloroform and petroleum extract of O.fruticosa. In the Las-A activity, the highest reduction in Las-A activity was seen in the chloroform extract of V.sinaiticum (70.5%) and also petroleum extract of V.sinaticum and chloroform extract O.fructicosa (70.3%).In the Pyocyanin assay, the chloroform extract of O.fructicosa and V.sinaiticum showed more significant effect in decreasing the Pyocyanin production by 81.8% and 79.5% respectively.