Journal for Nano Education – NanoScience and Nanotechnology

The Journal for NanoScience and Nanotechnology Education or Nanoeducation literature have been included in section part of ‘Journal of Materials NanoScience‘ under NanoEdu section.
The faculty members now can published their literary work required for teaching and learning of NanoScience and Nanotechnology concepts. The following type of work will be considered for publication

Lecture Notes: for undergraduate level or postgraduate level.
Chapters : Detailed chapters in field of nano.
Practical experimental details: If you are conducting experiments as part of curriculum study, then you can submit the details of experiments for undergraduate as well as postgraduate courses.

The chapters or NanoEdu articles should be prepared as per journal guidelines and submit on the journal site in NanoEdu section

Journal site: http://www.pubs.iscience.in/journal/index.php/jmns

When suitable number of articles on particular theme would have been published in the NanoEdu section of the journal, then these will also be compiled and published as book.

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Synthesis and Evaluation of [DUPA-6-Ahx-Lys (DOTA)-6-Ahx-RM2], a Novel, Bivalent Targeting Ligand for GRPr/PSMA Biomarkers of Prostate Cancer

In this study, we have prepared a novel, dual-biomarker, targeting ligand having high affinity and specificity for PSMA/GRPr receptors that are expressed on most prostate cancers. [DUPA-6-Ahx-Lys(DOTA)-6-Ahx-RM2] was synthesized and the new conjugate was metallated macroscopically with GaCl3, InCl3, and LuCl3 to form [DUPA-6-Ahx-Lys(M-DOTA)-6-Ahx-RM2] (where M = Ga, In, or Lu). These new agents, when radiolabeled with Ga-68, In-111, or Lu-177 hold theranostic potential for patients presenting with prostate cancer disease.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/718

      

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Synthesis and evaluation of a novel 68Ga-NODAGA-Erlotinib analogue towards PET imaging of Epidermal Growth Factor Receptor over-expressing cancers

In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of the terminal alkyne of Erlotinib using Cu catalyzed click reaction. The conjugate was then radiolabeled with 68Ga in high radiochemical yields. The 68Ga NODAGA-Erlotinib conjugate also exhibited high in vitro stability. The log P value of 68Ga-NODAGA-Erlotinib was lower than that of 68Ga-NOTA-Erlotinib, a 68Ga based Erlotinib conjugate previously reported by our group. In the in vitro cell binding studies carried out in EGFR-positive A431 cells, 68Ga-NODAGA-erlotinib exhibited an uptake (7.8±1.3 %) lower than that of 68Ga-NOTA-Erlotinib (9.8±0.4%) showing that an increase in hydrophilicity possibly effected a decrease in cell permeability. The higher hydrophilicity of 68Ga-NODAGA-Erlotinib also led to significantly lower accumulation of 68Ga-NODAGA-Erlotinib in non-target organs in the biodistribution studies in Swiss mice. The overall properties of the 68Ga-NODAGA-Erlotinib conjugate are promising and reflect the role of hydrophilicity in reducing the non-specific uptake of the final radiotracer towards improving signal/noise ratio for further imaging studies.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/727

      

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Dr Brijesh Rathi

Dr. Brijesh Rathi,
Department of Chemistry,
Hansraj College,
University of Delhi,
Delhi-110007. India

webpage: http://hansrajcollege.ac.in/faculty-info.php?id=28

Research Interests: Medicinal Chemistry, Maleria, Drug development, synthetic organic chemistry, peptide chemistry, peptide drugs, nanomedicine.

Dr. Brijesh Rathi is a faculty of Chemistry in Hansraj College, University of Delhi and associated with Chemical Biology Letters and Applied NanoMedicine as Editorial Board Member.

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Journal subscription procedure – Digital Edition

Journal subscription procedure for direct subscription on journal sites (Digital Edition)

Follow these steps to subscribe any of the ISP journal (Digital Edition)

1. Register and login on the respective journal site (see journals at http://pubs.iscience.in/journal )

2. Then go to ‘My subscription’ page on respective journal site, the link to page are
Chemical Biology Letters : http://pubs.iscience.in/journal/index.php/cbl/user/subscriptions
Journal of Biomedical and Therapeutic Sciences : http://pubs.iscience.in/journal/index.php/jbts/user/subscriptions
Journal of Materials NanoScience : http://pubs.iscience.in/journal/index.php/jmns/user/subscriptions

3. On this (My subscription) page, click on ‘Purchase new subscription’ link under Institutional Subscription.
– Fill the required details on the new page that opens; like Institute Name, IP Addresses etc. and then click on ‘Continue’.
– A new page will open with payment details; check info and click on ‘Continue’
– It will take you to Paypal/Payment gateway site.

As subscriptions for 2018 are free, do no make a payment. Just send an email with your user id to subs (at) iscience.in

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Just fill the form below and submit for processing by editorial office.

Institutional Subscriptions 2018:
Chemical Biology Letters ; USD 450 Nil
Journal of Biomedical and Therapeutic Sciences USD 450 Nil
Journal of Materials NanoScience USD 450 Nil

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Current trends in nanomedicine and nanobiotechnology research

Applications of Nanoparticles and nanopharmulations in drug development and drug delivery have been an extensive field of research to find out the alternative better therapeutics. The past research in nanomedicine and nanobiotechnology mostly emphasized on improving the profile of existing drugs, however, a recent pattern has seen in variation of field and aspects studied using nanomedicine. The current nanomedicine research has oriented in developing new drugs based on the interaction of nanoparticles on targets like cancer therapeutics, development of new biosensors, bioimaging (cellular and in vivo), new vistas of anti-viral drugs, besides the most researched field of nano delivery of drugs for cancer, diabetes, anti-bacterial, and other ailments. An overview of current research trends is presented based on the literature published at different platforms in recent time.

Source:: http://www.pubs.iscience.in/journal/index.php/appnanomed/article/view/747

      

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Synthesis of novel 2-(3-aryl/alkylamino propoxy)-12-aryl xanthene derivatives as antifungal and antibacterial agents

By admin By Bhaskara Nand, Kalawati Meena, Shruti Gupta, J.M. Khurana, Amita Malik, Chetan Sharma, Harsh Panwar A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H– benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. […]

Source:: http://pubs.iscience.in/synthesis-of-novel-2-3-arylalkylamino-propoxy-12-aryl-xanthene-derivatives-as-antifungal-and-antibacterial-agents/

      

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Synthesis of novel 2-(3-aryl/alkylamino propoxy)-12-aryl xanthene derivatives as antifungal and antibacterial agents

By Bhaskara Nand, Kalawati Meena, Shruti Gupta, J.M. Khurana, Amita Malik, Chetan Sharma, Harsh Panwar A series of novel 2-(3-aryl/alkylaminopropoxy)-12-aryl-9,10-dihydro-8H– benzo[a]xanthen-11-one derivatives were synthesized from 2-hydroxy-12-aryl 9,10-dihydro-8H-benzo[a]xanthen-11-ones by reaction with 1-bromo-3-chloropropane in presence of K2CO3 in dry acetone under reflux followed by reaction with aryl/alkyl amines in presence of KI in dry DMF at 100oC. Structures have been confirmed by spectroscopic analysis. All the newly synthesized 2-(3- aryl/alkylaminopropoxy)-12-aryl xanthene derivatives were screened for their antimicrobial activity against four microbial strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The selected synthesized compounds showed moderate antimicrobial activity.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/695

      

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A Comparative study on Glucose Levels in Serum and Saliva of Patients with Diabetes Mellitus and Healthy Individuals at Mullana Area

By admin By Sonam Bhalla, Asha Karadwal, Swati Roy, Vivek Dahiya The present study intends to compare and correlate serum & salivary glucose level in healthy & diabetic individuals. A total of 500 subjects were examined, of which 429 were healthy & 71 were confirmed diabetics. Post–prandial blood and salivary samples were analyzed. Mann-Whitney test using Pearson […]

Source:: http://pubs.iscience.in/a-comparative-study-on-glucose-levels-in-serum-and-saliva-of-patients-with-diabetes-mellitus-and-healthy-individuals-at-mullana-area/

      

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