Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents
urn:nbn:sciencein.cbl.2020v7.100
Published in Chemical Biology Letters
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Nidhi Singh
Amity University Uttar Pradesh
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Shridhar Satpute
Dr. Ambedkar College
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Naveen Polkam
Jawaharlal Nehru Technological University
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Ravi Kant
Shri Ramswaroop Memorial University
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Jaya Shree Anireddy
Jawaharlal Nehru Technological University
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Deepa Panhekar
Dr. Ambedkar College
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Jaya Pandey
Amity University Uttar Pradesh
Keywords:
4H-chromen-4-one, Oxidative Michael
addition, in-silico analysis, drug likeness
score, Molecular modelling, chromones
Abstract
A library of 28 newer 4H-chromen-4-one derivatives were designed, synthesized and screened for their antibacterial and antifungal efficacy against a panel of bacterial and fungal causative species. Fries and oxa-Michael protocols were employed to achieve the target compound. From the assayed, compounds 5c, 5e, 6a, 7b, 7d, 9a and 9b demonstrated promising anti-bacterial profile whereas products 6a, 7b, 8b and 9c elicited excellent anti-fungal properties. Further, in silico molecular properties were predicted for these sketched analogues to assess their bio availability and drug likeness by using molinspiration software/toolkit. None of them violated Lipinski’s rule of five, signifying them as better anti-bacterial and anti-fungal agents. Both in-silico and biological studies predict derivative 6a and 7b as best agent.
Cite as: Singh, N., Satpute, S., Polkam, N., Kant, R., Anireddy, J. S., Panhekar, D., & Pandey, J. (2020). Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents. Chemical Biology Letters, 7(1), 27-40.
Retrieve full text from http://thesciencein.org/journal/index.php/cbl/article/view/100 and http://www.pubs.iscience.in/journal/index.php/cbl/article/view/959