Open Access Open Access  Restricted Access Subscription Access
citokines male infertility

Cytokines and adipokines in the regulation of spermatogenesis and semen quality

Tulay Irez, Sermin Bicer, Elif Sahin, Sulagna Dutta, Pallav Sengupta


Male reproductive tract inflammation/infection possibly has direct association with the occurrence of male infertility. Semen quality has been reported to be markedly reduced in conditions of male reproductive tract inflammation owing to functional or anatomical alterations in the reproductive tract such as accessory glands dysfunctions, obstructions in sperm transport, or spermatogenic disruptions by the inflammatory microenvironment. The severity of the inflammatory process and the level of impairment in male reproductive functions are associated with the roles played by individual inflammatory mediators, prominently the cytokines, adipokines and the reactive oxygen species (ROS). The mutual interactions of these biologically active substances originating mostly from the activated seminal leukocytes adversely affect testicular functions and deteriorate semen quality. However, several aspects regarding the association of inflammation, pro-inflammatory mediators and male infertility need to be clarified. Thus, the current review aims to present the roles of cytokines and adipokines in the context of understanding the mechanisms of inflammation-induced alterations in semen quality.


adipokines; cytokines; inflammation; male infertility; reactive oxygen species; semen quality

Full Text:


ISSN 2347–9825

Authors/visitors are advised to use Firefox browser for better experience of journal site.

Open Access: Researcher from developing/low economy countries can access the jorunal contents through WHO-HINARI .