Medicinal Chemistry in Anti-Cancer and Anti-HIV advances – Special Issue of Chemical Biology Letters

The two prominent diseases i.e Cancer and HIV infections has been putting a challenge to researchers community to find a reliable treatment. There have been newer developments and research advances in finding the cure for these by using chemistry biology interface research. To collect the advances in the filed, a special issue on anti-cancer and anti-HIV therapeutics development would be published in Chemical Biology Letters. The issue will cover the themes (though not limited to as field and research is wide):

– Kinase Inhibitor advances
– new targets for anti-cancer molecules
– development in anti-HIV therapeutics
– Medicinal Chemistry of Anti-Cancer drugs
– Medicinal Chemistry of anti – HIV molecules
– Development in drug delivery systems for anti-cancer and anti-HIV drugs
– Peptides based drug delivery
– Peptide therapeutics
– targeted drug delivery
– Small molecules and Heterocyclic molecules for anti-cancer and anti-HIV therapy

The Medicinal Chemistry community is invited to contribute a ‘Review Article’ ‘Research Article’ or ‘Short Communication’ for processing in special issue.

Submission: The manuscript should be prepared as per details provided on Author Guidelines page: http://pubs.thesciencein.org/author-guidelines-chemical-biology-journal/

The article should be submitted online on the journal site at http://pubs.thesciencein.org/journal/index.php/cbl

Last date for submission of manuscript: November 30, 2018.

Edited by

Dr Rakesh
Prof. Keykavous Parang
Associate Dean of Research, Graduate Studies, and Global Affairs
Professor of Medicinal Chemistry and Pharmacology
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Rd.
Irvine, CA 92618-1908. USA
Email: parang@chapman.edu
Dr. Rakesh Tiwari
Chapman University
School of Pharmacy (CUSP)
Harry & Diane Rinker Health Science Campus
9501 Jeronimo Road Rm 241
Irvine, CA 92618
Email: tiwari@chapman.edu

Chemical Biology Letters is indexed in SCOPUS, CAS, CNKI, Google Scholar and other popular indexing databases.

Source:: http://pubs.thesciencein.org/medicinal-chemistry-in-anti-cancer-and-anti-hiv-advances-special-issue-of-chemical-biology-letters/

      

Mechanistic approach of anti-diabetic compounds identified from natural sources

Type-2 diabetes mellitus (T2DM) is a global disease, which leads to various other life threatening diseases and affects the quality of life. Current therapies of T2DM have various side effects and ultimately lead to insulin resistance, along with financial burden. Therefore, comparative study of natural compounds along with their mechanisms has been discussed, which may lead toward the better understanding about their efficacy and selection of future anti-diabetic drugs. Traditional medicine is promising to treat T2DM, where more than 200 plants and other species are shown to have anti-T2DM effects. Moreover, these natural products have different types of molecular mechanisms, i. e. β-cell regeneration, insulin mimicry, AMPK, Akt, PPARs, LXR activation and inhibition of α-glucosidase, TNF- α, sodium glucose co- tranporters and oxidative stress. At the same time numbers of compounds have been reported to have in vivo efficacy. As a number of investigators speculated the molecular mechanism of these natural opmpounds, hence this review is focused on the molecular mechanism of different types of natural anti-diabetic molecules and their classes along with their efficacy in animal models. This review will provide a broad idea about anti-diabetic compounds to scientific and common people and will help to choose the dietary components and traditional medicines effective in T2DM.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/834

      

Synthesis and biodegradation study of Starch/PVA/Nanoclay blend

In this proposed project we have synthesized blend of starch/PVA/nanoclay via solution cast method. The composition of blend was starch and PVA in 1:1 ratio by weight with citric acid as plasticizer. The amount of nanoclay was varied between 0.5 to 2 wt%. The structure elucidation of the film by Scanning electron microscopy reveals homogeneous dispersion of nanoclay into polymer matrix. The biodegradation of the films were studied by soil burial method and enzymatic hydrolysis and it was found that completely biodegradable films were produced which could serve as potential candidate for food packaging.

Source:: http://www.pubs.iscience.in/journal/index.php/jmns/article/view/831

      

Author Guidelines Chemical Biology Journal

Information for Authors

The Authors need to submit a single file containing all the details as described below. The supplementary data files should be submitted as a separate file. A cover letter and graphical abstract should be submitted along with manuscript as details provided below.

Cover letter

Authors should supply a cover letter indicating rational of their work. Cover letter should also have details of at least three reviewers (with email). Cover letter should be provided on the first step of submission in “Comments for Editor’ box.

Graphical Abstract

Authors need to submit a graphical abstract highlighting the contents of manuscript. The guidelines for graphical abstract preparation and submission are available on this link.

Manuscript

Manuscript should include Title, Author (s), Affiliation (complete name of institutions), Abstract, 5 Keywords, (other sections like Introduction, Results and discussion, conclusion, experimental procedures in the main body text of manuscript could be used for full paper article), acknowledgment and references in the listed order. Short communications need not to be arranged in different sections. References should be formatted as shown for articles,1 theses,2 books,3,4 and patents,5

1. R. Ping, M. Laura, P.S. Mario. Title of the journal article should be included here. Int. Lett.Org. Chem. 1996, 61, 4439–4449.

2. B.K. Sharma. Ph.D. Dissertation, Thesis Title, Cornell University, 1995.

3. R. Hussain, D. Shinkoi. Title of book like Synthesis and application of ionic liquid, John Wiley & Sons: New York, 2010.

4. R.S. Buchanod, D.K. Reddy. In Selective Organic Transformations; T.R. Thyagarajan, Ed.; Integrated science: New York, 2002; Vol. 2, pp 1–95.

5. G.L. Loyale, U.S. Patent 5 934 456, 1998; Chem. Abstr. 1998, 65, 2870.

Citation Manager style files: Authors are highly encouraged to use the citation manager programs for citing and formatting the references. Authors may use free Mendelay, Zotero, Paper 2 or Endnote program. If you are using any of these citation manager program for Bibliography (References and Notes), then you can download citation style file for journal (common for ISP journals):

Mendelay, Zotero, Paper 2 style file: ISP Journals CSL style file

Endnote style file: ISP Journals Endnote style file Or ChemBiolLett style file (click and download from google drive … and copy the file to Endnote style folder or open in EndNote).

click to download and then open in respective program (the user can see the respective program user guide on how to use the style file).

Submission

Authors need to submit all manuscripts through journal website. Register by following link ‘Register’ above (make sure to mark checked the options Author and reviewer while registering for journal). On login, you will find ‘new submission’ link in your panel page.

For review purpose, author can submit the manuscript as outlined above. However, Authors are advised to prepare their manuscript according to journal article template (provided below) as it progress towards acceptance. On acceptance of manuscript, authors must need to supply their manuscript in Article template (if they have not already submitted in template). If you face difficulty in preparing manuscript according to template, then you can forward your manuscript (place all figures with caption in the end of file) to Copyeditor/Support department ( pubs@thesciencein.org )

Templates

On acceptance of manuscript, Authors are required to submit revised manuscript in journal articles template (If authors wish, they are free to submit their manuscript in journal article template while submitting first time).

ChemBioLett_Word2007-2010_template click to download from google drive

download the template (as per the MS Word version that you have on your computer), double click the file to open and then prepare your article and save it with your own name.

Login and submit the manuscript online (submission by email are not accepted). Only online submissions are accepted now.

Authors are advised to contact Support, CBL (email: pubs @ thesciencein.org ) if there is any problem in registration or submission.

Declaration of Conflict of Interest

Authors should mention any conflict of interest in the work submissted to Chemical Biology Letters. The statement about conflict of interest may be mentioned in the ‘Letter to editor’ or placed in the manuscript after acknowledgement section.

Ethical Uses Declaration:

If the manuscript report the experimentation on animals (including clinical trials on human beings), then declaration about ethical way handling of animals and about keeping the complete privacy of human identity (in case of clinical trials) must be mentioned in the manuscript.

Helsinki Declaration (contents from NIH-NLM): When reporting experiments on human subjects, authors should indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). If doubt exists whether the research was conducted in accordance with the Helsinki Declaration, the authors must explain the rationale for their approach, and demonstrate that the institutional review body explicitly approved the doubtful aspects of the study. When reporting experiments on animals, authors should be asked to indicate whether the institutional and national guide for the care and use of laboratory animals was followed.

Submission:

Submit manuscript on journal editorial processing site at

http://pubs.thesciencein.org/journal/index.php/cbl

Source:: http://pubs.thesciencein.org/author-guidelines-chemical-biology-journal/

      

Antituberculer Schiffs Bases Prepared from Biologically Active Substituted Benzaldehydes to Enhance Drug likeness

In a preliminary screening we found that many substituted benzaldehyde showing promising anti-tubercular (anti-TB) activity. Study was planned to convert these substituted benzaldehyde to anti-tubercular schiffs bases. Various schiffs bases were synthesized by condensation of 2-Amino pyridine (or its derivative) or Thiophene or Furoic or Nicotinic acid hydrazide with anti-tubercular benzaldehydes. Compounds were purified, crystallized and characterized by IR,1H and 13C-NMR. Initial Anti-tubercular screening was carried out in fast growing Mycobacterial strain Mycobacterium smegmatis (M. smeg.) by disc diffusion method. Further quantitative estimation of anti-tubercular activity was carried out in Mycobacterium bovis (M. bovis) BCG vaccine strain using Resazurin Microplate Assay (REMA). Schiffs bases prepared from salisaldehyde or p-NO2 benzaldehyde with 2- amino pyridine (3c and 3f) and 2, 3 dihydroxy benzaldehyde with nicotinic acid hydrazide (8a) have shown anti-TB potential. Anti-TB activity of synthesized compounds was reported at higher concentration (500µg/mL) with respect to standard drug isoniazid INH (40µg/mL), because there was no earlier report or MIC data of synthesized Schiffs bases. Compounds 3c, 3f and 8a have shown 60, 40 and 50 mm zone of inhibition in M. smegmatis compared to vector control, INH has shown 40 mm zone of inhibition. In Mycobacterium bovis, Schiffs bases 3c,3f and 8a have shown 53.69, 49.41, 46.49 % inhibition at 500 µM concentration, the activity was concentration dependent and lower inhibition of 29.73, 37.75 and 36.15% were observed at 125 µM concentration by the compound 3c and 3f and 8a respectively. Standard drug INH has shown 60% inhibition at 40 µg/ml concentration. The anti-TB activity of banzaldehydes depends on various substitutions, Nitro or methoxy or hydroxyl substituted benzaldehydes were anti-TB while halogenated benzaldehydes are inactive. Preparation of Schiff’s bases may be one of the ways to enhance activity, introduce drug likeness in the active benzaldehyde, may represent low toxicity and high bioavailability.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/818

      

Microwave assisted greener synthesis of silver nanoparticles using karanjin and their antifungal activity

In recent days, the synthesis of nanoparticles using biomaterials is growing very rapidly due to their non toxicity and eco friendliness. In the present study we demonstrated the role of individual organic compounds present in the plant extracts in the synthesis of silver nanoparticles (Ag NPs) using Karanjin, a natural flavonoid extracted from seeds of Pongamia pinnata L. assisted by microwave technique. The plasmon resonance absorbance peak was observed at 424 nm in UV–visible spectroscopy. The TEM results showed presence of spherical shape with ~20 nm in size. The FTIR spectrum indicates there is no organic molecule present in the powder material and it confirms the formation of Ag NPs by microwave method. Further, confirmed by X-ray diffraction (XRD) and Energy Dispersive Spectroscopy (EDS) analysis. AFM images explained the topography of the Ag NPs. The obtained nanoparticles were stable and it confirms the activity of Karanjin as a reducing and capping agent in synthesis of Ag NPs. The synthesized Ag NPs demonstrated good antifungal activity against Aspergillus flavus and A. niger.

Source:: http://www.pubs.iscience.in/journal/index.php/jmns/article/view/814

      

WITHDRAWN: Synthesis of Zn-Loaded TiO2 Electrospun Nanofibers for Photocatalytic Decolorization of Methylene Blue

Titanium dioxide (TiO2) is one of the excellent photocatalysts used for degradation of environmetal pollutants. In this work, 1, 2, 3 and 4 wt.% of zinc (Zn)-loaded TiO2 nanofibers of mean size 45-80nmwere synthesized by electrospinning method. These electrospun nanofibers were calcined at 600°C to enable the transformation of Rutile (R) phase to Anatase (A), elimination of reaction moieties from the TiO2 matrix and subsequently formation of Zn clusters. The effect of Zn loading on the morphology, crystal structure, phase transformation, and band gap of these electrospun nanofibers have been characterized by Scannining Electron Microscopy (SEM), (EDX), X-ray Diffraction (XRD), Photoluminescence (PL), Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy and UV-Visible Spectroscopy. These nanofibers exhibited a red-shift in the absorbance edge and a significant enhancement of light absorption in the wavelength range of 250–550nm. These electrospun nanofibers were investigated for photodecomposition of methylene blue (MB), and photocatalytic decolorization rates were determined by pseudo-first-order equation. The rate constants for the pure and those of 1, 2, 3 and 4 wt% Zn-loaded TiO2 nanofibers were computed to be 0.1439min-1, 0.1608min-1, 0.1876min-1, 0.20123 min-1 and 0.2251min-1 respectively.

Source:: http://www.pubs.iscience.in/journal/index.php/jmns/article/view/816

      

NanoChemistry – Chemistry of Nanomaterials | Special Issue of Journal of Materials NanoScience

Dr. RS Verma materials nanoscience

NanoChemistry covers the development in new chemistry for nanomaterials synthesis and applications. The chemistry in the field of nanoscience and nanotechnology is advancing at a fast pace and bringing the new methodologies, chemical procedures for synthesis of nanomaterials along with development of new type of nanomaterials. The application field of nanochemistry is spreading to new areas including nanocatalysis, nanomedicine, nanoconjugates, nanophysics of chemistry materials, nanobatteries, semiconductors and so on. A special issue covering the recent advances in chemistry of nanomaterials will cover following fields (though not limited to as field is advancing at fast pace):

  • Nanofullerenes
  • Carbon Nanotubes
  • Graphene
  • Nanocatalysis – development of new nanocatalysts and applications thereof.
  • Nanoscience chemistry of fuel materials
  • Chemistry of Nanoenergy materials
  • NanoChips (semiconductor designing and development using new materials chemistry)
  • Nanobattery and nanofuel cells
  • Inorganic Chemistry development in nanoparticles and applications thereof like gold nanoparticles, silver nanoparticles, iron and magnetic nanoparticles, quantum dots, and other metal /alloy nanoparticles.

The articles are invited from Chemical Sciences fraternity for publication in special issue. The Review articles, Original Research Articles, Short Communication, Expert Opinion would be considered for processing in the issue.

Author Guidelines are provided on the link: JMNS Author Manuscript preparation Guidelines

Submission: Authors need to submit their manuscript as per author guidelines on the journal Editorial Manager /manuscript processing site http://pubs.thesciencein.org/journal/index.php/jmns (or alternatively can be submitted by email at pubs@thesciencein.org )

Date of early Submissions: October 30, 2018

Issue Editing Support by

Dr. Rajender S. Verma,
U. S. Environmental Protection Agency
ORD, National Risk Management Research Laboratory
Water Systems Division/ Water Resources Recovery Branch
26 West Martin Luther King Drive, MS 443
Cincinnati, Ohio 45268, USA EB

Associate Editor and Senior Advisor

Research interest: NanoChemistry, Nanocatalysis, Nanoscience, nanomaterials.

Source:: http://pubs.thesciencein.org/nanochemistry-chemistry-of-nanomaterials-special-issue-of-journal-of-materials-nanoscience/

      

Author Guidelines for Journal of Nanomaterials | Materials NanoScience

The Authors need to submit a single file containing all the details as described below. The supplementary data files should be submitted as a separate file. Authors are advised to prepare their manuscript according to journal article template provided below.

Cover letter

Authors should supply a cover letter indicating rational of their work. Cover letter should also have details of at least three reviewers (with email). Cover letter should be provided on the first step of submission in “Comments for Editor’ box.

Graphical Abstract

Authors need to submit a graphical abstract highlighting the contents of manuscript. Graphical abstract could be submitted as supplementary file or on the last page of manuscript. The preferred image size of graphical abstract is 700px x 250px

Manuscript

Manuscript should include Title, Author (s), Affiliation (complete name of institutions), Abstract, 5 Keywords, (other sections like Introduction, Results and discussion, conclusion, experimental procedures in the main body text of manuscript could be used for full paper article), acknowledgment and references in the listed order. Short communications need not to be arranged in different sections. References should be formatted as shown for articles,1 theses,2 books,3,4 and patents,5

1. R. Ping, M. Laura, P.S. Mario. Title of the journal article should be included here. Int. Lett.Org. Chem. 1996, 61, 4439–4449.

2. B.K. Sharma. Ph.D. Dissertation, Thesis Title, Cornell University, 1995.

3. R. Hussain, D. Shinkoi. Title of book like Synthesis and application of ionic liquid, John Wiley & Sons: New York, 2010.

4. R.S. Buchanod, D.K. Reddy. In Selective Organic Transformations; T.R. Thyagarajan, Ed.; Integrated science: New York, 2002; Vol. 2, pp 1–95.

5. G.L. Loyale, U.S. Patent 5 934 456, 1998; Chem. Abstr. 1998, 65, 2870.

Citation Manager style files: Authors are highly encouraged to use the citation manager programs for citing and formatting the references. Authors may use free Mendelay, Zotero, Paper 2 or Endnote program. If you are using any of these citation manager program for Bibliography (References and Notes), then you can download citation style file for journal (common for ISP journals):

Mendelay, Zotero, Paper 2 style file: ISP Journals CSL style file

Endnote style file: ISP Journals Endnote style file Or ChemBiolLett style file (click and download from google drive … and copy the file to Endnote style folder or open in EndNote).

click to download and then open in respective program (the user can see the respective program user guide on how to use the style file).

On acceptance of manuscript, authors must need to supply their manuscript in Article template (if they have not already submitted in template).

Submission

Authors need to submit all manuscripts through journal website. Register by following link ‘Register’ above (make sure to mark checked the options Author and reviewer while registering for journal). On login, you will find ‘new submission’ link in your panel page.

Templates

On acceptance of manuscript, Authors are required to submit revised manuscript in journal articles template (If authors wish, they are free to submit their manuscript in journal article template while submitting first time).

Materials NanoScience_Word2007-2010_template (click and download from google drive..)

download the template (as per the MS Word version that you have on your computer), double click the file to open and then prepare your article and save it with your own name.

Login and submit the manuscript online (submission by email are not accepted). Only online submissions are accepted now.

On acceptance of manuscript, Authors need to send ‘Copyright Transfer form’ (signed by all authors).

Source:: http://pubs.thesciencein.org/author-guidelines-for-journal-of-nanomaterials-materials-nanoscience/

      

International Journal of Nanomedical Sciences

The International Journal of NanoMedical Sciences is a peer reviewed international journal for publication of research advances in nanomedicine and nanobiotechnology. It is continuation of ‘Applied NanoMedcine’ journal in new form and name.

Editor-in-Chief

Dr. B.S. Chhikara
University of Delhi

Associate Editors

Dr. Avinash Bajaj
Regional Centre for Biotechnology

Dr. Gajadhar Bhakta
Institute of Medical Biology
Agency for Science, Technology and Research (A*STAR)

International Editorial Board

Prof. Vincent M. Rotello
University of Massachusetts

Dr. Prabagaran Narayanasamy
Nebraska Medical Center

Dr. Nidhi Lal
University of Leed

Dr. Sivashankar Krishnamoorthy
Luxembourg Institute of Science and Technology

Dr. M. Saravanan
Mekelle University

Prof. U. C. Banerjee
National Institute of Pharmaceutical Education and Research (NIPER)

Dr. Santosh K. Mishra
University of Illinois at Urbana-Champaign, Urbana, IL

Dr. Brijesh Rathi
Massachusetts Institute of Technology

Dr. Shruti Padhee
Torrey Pines Institute for Molecular Studies

Dr. Biman B. Mandal
Indian Institute of Technology Guwahati (IITG)

Dr. Santanu Dhara
IIT Kharagpur

Dr. Asish Pal
Institute of Nano Science and Technology

Dr. Sumit Kumar
DCR University of Science and Technology

Dr. Manzoor Koyakutty
Amrita Vishwa Vidyapeetham (University)

Dr. Mohd Zobir Hussein
Universiti Putra Malaysia (UPM)

Focus and Scope

The journal publishes research advances in field of nanomedicine and nanobiotechnology covering the following subtopics (though not limited to):

Clinical Nanomedicine, Targeted and stimuli-responsive drug delivery, Biosensors, Ultrasensitive biosensing and in vitro diagnostics, Nanobioimaging, Multimodal in vivo bioimaging, Nanotheranostics, Nanoradiopharmaceuticals, Nanoscience and nanotechnology in Tissue engineering and regenerative medicine, Nanotoxicology, Emergency nanomedicine, Nanoformulation of natural products, Nanodrugs and drug target interactions, Non-viral gene therapy, Nanorobotics, Ethical and policy aspects related to nanomaterials, Nanomaterials in food with possible medical effects.

The International Journal of Nanomedical Sciences is accepting articles from the nanomedicine community and publishing the contents in the journal ‘Applied NanoMedicine’ till the journal launch its full functions (under processing with full swing for earliest beginning.
Authors may submit their articles in the Applied Nanomedicine at the link http://www.pubs.iscience.in/journal/index.php/appnanomed/about/submissions