Monthly Archives: September 2018

Nanomaterials Frontiers

Nanomaterials Frontiers is meant to cover exciting new and recent research advances in field of nanomaterials, smart materials development, new notable technological advances at nanometer scale research and path breaking research finding in nanomaterials advances. The Frontier research in nanomaterials covered from all literary sources highlighted as breakthrough findings in form of summarized reports ‘Nanomaterials Frontiers’ be published combined in print form of ‘Journal of Materials NanoScience’, however, selected highlights will be published online. The summarized highlights would provide a quick grasp of latest advances to scientists and young researchers.
Researchers are invited to submit the reports for covering in highlights/frontiers as small summary write up in simple lucid presentation (for easy understanding by novice researchers) extending upto 2 pages (the report should include new title and 2-3 paragraphs summary along with references to original source). Submit by email to pubs @ thesciencein .org or may submit by form below.

Source:: http://pubs.thesciencein.org/nanomaterials-frontiers/

      

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Synthesis and Biodegradation Study of Starch/PVA/Nanoclay Blend

urn:nbn:sciencein.jmns.2018v5.60

Synthesis and Biodegradation Study of Starch/PVA/Nanoclay Blend

Geeta Saini University of Delhi
Himani Chauhan University of Delhi
Aeshna Gupta University of Delhi
Disha Gangotia University of Delhi

Keywords: Food packaging, Nanoclay, Biodegradable, PVA, Starch
Abstract

In this research work, we have synthesized blend of starch/PVA/nanoclay via solution cast method. The composition of blend was starch and PVA in 1:1 ratio by weight with citric acid as plasticizer. The amount of nanoclay was varied between 0.5 to 2 wt%. The structure elucidation of the film by Scanning electron microscopy reveals homogeneous dispersion of nanoclay into polymer matrix. The biodegradation of the films were studied by soil burial method and enzymatic hydrolysis and it was found that completely biodegradable films were produced which could serve as potential candidate for food packaging.

Link http://pubs.thesciencein.org/journal/index.php/jmns/article/view/60

Source:: http://pubs.thesciencein.org/urnnbnsciencein-jmns-2018v5-60/

      

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Herbal nanomedicine interactions to enhance pharmacokinetics, pharmaco-dynamics, and therapeutic index for better bioavailability and biocompatibility of herbal formulations

urn:nbn:sciencein.jmns.2018v5.61

Herbal nanomedicine interactions to enhance pharmacokinetics, pharmaco-dynamics, and therapeutic index for better bioavailability and biocompatibility of herbal formulations

Rajiv Kumar University of Delhi
Munesh Sharma Arogya Nidhi Ayurveda Clinic

Keywords: Phyto-medicine, Hydrophilicity, Nanocarriers, Drug Delivery
Abstract

The recent technological advancement in nanotechnology has opened new avenues for research and development in the field of phyto-medicine. Development of reliable and eco-friendly synthesis of nanoparticles is a significant advancement for introduction nanotechnology to develop noble nanomedical delivery system of herbs (HNMDS), and have to overcome the downsides of old-style herbs-medicines delivery through analyzing the interactions between nanocarriers and herbs or phyto-medicine. The application of nanotechnological methods for bioavailability and biocompatibility enhancement of phyto-medicine must be reviewed and need urgent prompt efforts to develop new formulations. Nanotechnology enables the combination of hitherto separate approaches to health care by permitting the realization of so-called ‘theranostic’ applications, as well as targeted combination products. Formulation must also release active ingredient from phyto-formulation as developing nano dosage forms has number of benefits for phyto-medicine. This review discusses nano sized herbs-nanomedicines delivery carries and potential current and futuristic advances for enhancing the activity and overcoming problems associated with herbal medicines for novel HNMDS.

Link: http://pubs.thesciencein.org/journal/index.php/jmns/article/view/61

Source:: http://pubs.thesciencein.org/urnnbnsciencein-jmns-2018v5-61/

      

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Herbal nanomedicine interactions to enhance pharmacokinetics, pharmaco-dynamics, and therapeutic index for better bioavailability and biocompatibility of herbal formulations

The recent technological advancement in nanotechnology has unlocked new avenues for research and development in the field of phyto-medicine. Development of reliable and eco-friendly synthesis of nanoparticles is a significant advancement for starter nanotechnology to develop noble nanomedical delivery system of herbs (HNMDS), and have to overcome the downsides of old-style herbs-medicines delivery means through analyzing the interactions between nanocarriers and herbs or phyto-medicine. The application of nanotechnological ways and means for bioavailability and biocompatibility enrichment of phyto-medicine must be reread and need swift efforts to develop new formulations. Nanotechnology empowers the combination of hitherto separate approaches to health care by letting the realization of so-called ‘theranostic’ applications, as well as besieged blend products. Formulation must also release active ingredient from phyto-formulation as emerging nano dosage forms having number of benefits existed earlier in phyto-medicine. This assessment converses nano sized herbal nanomedicines delivery carries, potential current and ultramodern advances for enhancing the activity and overcoming problems associated with herbal medicines for the development of novel HNMDS. Clinical Pharmacokinetics is discussed in view of the impression of advance of drug absorption, distribution, metabolism, and excretion as per the entitlement of pharmacokinetic principles of the harmless and actual therapeutic applications of herbal nanomedical medications.

Source:: http://www.pubs.iscience.in/journal/index.php/jmns/article/view/835

      

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Medicinal Chemistry in Anti-Cancer and Anti-HIV advances – Special Issue of Chemical Biology Letters

The two prominent diseases i.e Cancer and HIV infections has been putting a challenge to researchers community to find a reliable treatment. There have been newer developments and research advances in finding the cure for these by using chemistry biology interface research. To collect the advances in the filed, a special issue on anti-cancer and anti-HIV therapeutics development would be published in Chemical Biology Letters. The issue will cover the themes (though not limited to as field and research is wide):

– Kinase Inhibitor advances
– new targets for anti-cancer molecules
– development in anti-HIV therapeutics
– Medicinal Chemistry of Anti-Cancer drugs
– Medicinal Chemistry of anti – HIV molecules
– Development in drug delivery systems for anti-cancer and anti-HIV drugs
– Peptides based drug delivery
– Peptide therapeutics
– targeted drug delivery
– Small molecules and Heterocyclic molecules for anti-cancer and anti-HIV therapy

The Medicinal Chemistry community is invited to contribute a ‘Review Article’ ‘Research Article’ or ‘Short Communication’ for processing in special issue.

Submission: The manuscript should be prepared as per details provided on Author Guidelines page: http://pubs.thesciencein.org/author-guidelines-chemical-biology-journal/

The article should be submitted online on the journal site at http://pubs.thesciencein.org/journal/index.php/cbl

Last date for submission of manuscript: November 30, 2018.

Edited by

Dr Rakesh
Prof. Keykavous Parang
Associate Dean of Research, Graduate Studies, and Global Affairs
Professor of Medicinal Chemistry and Pharmacology
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Rd.
Irvine, CA 92618-1908. USA
Email: parang@chapman.edu
Dr. Rakesh Tiwari
Chapman University
School of Pharmacy (CUSP)
Harry & Diane Rinker Health Science Campus
9501 Jeronimo Road Rm 241
Irvine, CA 92618
Email: tiwari@chapman.edu

Chemical Biology Letters is indexed in SCOPUS, CAS, CNKI, Google Scholar and other popular indexing databases.

Source:: http://pubs.thesciencein.org/medicinal-chemistry-in-anti-cancer-and-anti-hiv-advances-special-issue-of-chemical-biology-letters/

      

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Mechanistic approach of anti-diabetic compounds identified from natural sources

Type-2 diabetes mellitus (T2DM) is a global disease, which leads to various other life threatening diseases and affects the quality of life. Current therapies of T2DM have various side effects and ultimately lead to insulin resistance, along with financial burden. Therefore, comparative study of natural compounds along with their mechanisms has been discussed, which may lead toward the better understanding about their efficacy and selection of future anti-diabetic drugs. Traditional medicine is promising to treat T2DM, where more than 200 plants and other species are shown to have anti-T2DM effects. Moreover, these natural products have different types of molecular mechanisms, i. e. β-cell regeneration, insulin mimicry, AMPK, Akt, PPARs, LXR activation and inhibition of α-glucosidase, TNF- α, sodium glucose co- tranporters and oxidative stress. At the same time numbers of compounds have been reported to have in vivo efficacy. As a number of investigators speculated the molecular mechanism of these natural opmpounds, hence this review is focused on the molecular mechanism of different types of natural anti-diabetic molecules and their classes along with their efficacy in animal models. This review will provide a broad idea about anti-diabetic compounds to scientific and common people and will help to choose the dietary components and traditional medicines effective in T2DM.

Source:: http://www.pubs.iscience.in/journal/index.php/cbl/article/view/834

      

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Synthesis and biodegradation study of Starch/PVA/Nanoclay blend

In this proposed project we have synthesized blend of starch/PVA/nanoclay via solution cast method. The composition of blend was starch and PVA in 1:1 ratio by weight with citric acid as plasticizer. The amount of nanoclay was varied between 0.5 to 2 wt%. The structure elucidation of the film by Scanning electron microscopy reveals homogeneous dispersion of nanoclay into polymer matrix. The biodegradation of the films were studied by soil burial method and enzymatic hydrolysis and it was found that completely biodegradable films were produced which could serve as potential candidate for food packaging.

Source:: http://www.pubs.iscience.in/journal/index.php/jmns/article/view/831

      

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