The two prominent diseases i.e Cancer and HIV infections has been putting a challenge to researchers community to find a reliable treatment. There have been newer developments and research advances in finding the cure for these by using chemistry biology interface research. To collect the advances in the filed, a special issue on anti-cancer and anti-HIV therapeutics development would be published in Chemical Biology Letters. The issue will cover the themes (though not limited to as field and research is wide):
– Kinase Inhibitor advances
– new targets for anti-cancer molecules
– development in anti-HIV therapeutics
– Medicinal Chemistry of Anti-Cancer drugs
– Medicinal Chemistry of anti – HIV molecules
– Development in drug delivery systems for anti-cancer and anti-HIV drugs
– Peptides based drug delivery
– Peptide therapeutics
– targeted drug delivery
– Small molecules and Heterocyclic molecules for anti-cancer and anti-HIV therapy
The Medicinal Chemistry community is invited to contribute a ‘Review Article’ ‘Research Article’ or ‘Short Communication’ for processing in special issue.
Submission: The manuscript should be prepared as per details provided on Author Guidelines page: http://pubs.thesciencein.org/author-guidelines-chemical-biology-journal/
The article should be submitted online on the journal site at http://pubs.thesciencein.org/journal/index.php/cbl
Last date for submission of manuscript: November 30, 2018.
| Prof. Keykavous Parang
Associate Dean of Research, Graduate Studies, and Global Affairs
Professor of Medicinal Chemistry and Pharmacology
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Rd.
Irvine, CA 92618-1908. USA
| Dr. Rakesh Tiwari
School of Pharmacy (CUSP)
Harry & Diane Rinker Health Science Campus
9501 Jeronimo Road Rm 241
Irvine, CA 92618
Chemical Biology Letters is indexed in SCOPUS, CAS, CNKI, Google Scholar and other popular indexing databases.
Type-2 diabetes mellitus (T2DM) is a global disease, which leads to various other life threatening diseases and affects the quality of life. Current therapies of T2DM have various side effects and ultimately lead to insulin resistance, along with financial burden. Therefore, comparative study of natural compounds along with their mechanisms has been discussed, which may lead toward the better understanding about their efficacy and selection of future anti-diabetic drugs. Traditional medicine is promising to treat T2DM, where more than 200 plants and other species are shown to have anti-T2DM effects. Moreover, these natural products have different types of molecular mechanisms, i. e. β-cell regeneration, insulin mimicry, AMPK, Akt, PPARs, LXR activation and inhibition of α-glucosidase, TNF- α, sodium glucose co- tranporters and oxidative stress. At the same time numbers of compounds have been reported to have in vivo efficacy. As a number of investigators speculated the molecular mechanism of these natural opmpounds, hence this review is focused on the molecular mechanism of different types of natural anti-diabetic molecules and their classes along with their efficacy in animal models. This review will provide a broad idea about anti-diabetic compounds to scientific and common people and will help to choose the dietary components and traditional medicines effective in T2DM.
In this proposed project we have synthesized blend of starch/PVA/nanoclay via solution cast method. The composition of blend was starch and PVA in 1:1 ratio by weight with citric acid as plasticizer. The amount of nanoclay was varied between 0.5 to 2 wt%. The structure elucidation of the film by Scanning electron microscopy reveals homogeneous dispersion of nanoclay into polymer matrix. The biodegradation of the films were studied by soil burial method and enzymatic hydrolysis and it was found that completely biodegradable films were produced which could serve as potential candidate for food packaging.