By Ashish Bhatt, Rajesh Kumar Singh, Ravi Kant A new class of 1,3,4-thiadiazole derivatives 8a-i incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties were synthesized by the reaction of arylidene derivatives of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety (Schiff base) 7a-i with thioglycolic acid. Schiff base 7a-i were synthesized by the reaction of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety 6 with substituted benzaldehyde. These were screened for in-vitro antimicrobial activity against two gram positive (Streptococcus Pyogenes and Staphylococcus aureus) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli) as well as for antifungal and antimalarial activity against plasmodium falciparum strain. Compound 8a and 8b exhibited good antimicrobial and antimalarial activity.
By Surajit Baksi, Mukandar Khan, Mamta Panchal, Nirav Rao Hyaluronic acid (HA) is a biopolysacharride present in connective tissues of body. It has high significant economic concern due to its high use in medical, cosmetic and food industries. It is present in several resources like rooster combs, eye and umbilical cord. Due to its good chemical and physical properties, it is used in ophthalmic and osteoarthritic surgeries. Presently, it is produced from animal and bacterial sources. But, the percentage yield is very less at large scale. In present study, effort was done to increase yield of HA from Streptococcus zooepidemicus, through modification of the fermentation and extraction process. The cell concentration and HA concentration was measured which showed that HA concentration increased with induced pH stress.